Product image of Levodopa + Carbidopa + Entacapona Pentafarma (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa + Carbidopa + Entacapona Pentafarma

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa + Carbidopa + Entacapona Pentafarma (Carbidopa, Entacapone, Levodopa)

Levodopa, Carbidopa, Entacapone, the active ingredient in Levodopa + Carbidopa + Entacapona Pentafarma, is a combination dopamine precursor and COMT inhibitor presented as an oral tablet for oral use. It is indicated for the management of Parkinson's disease, helping to control motor symptoms and reduce OFF periods in patients.

GNH India supplies Levodopa + Carbidopa + Entacapona Pentafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the Parkinson's disease therapeutic pathway to improve motor control and reduce fluctuations.

  • Parkinson's disease: improves overall motor symptoms and reduces OFF time.
  • Parkinson's disease with wearing‑off: provides smoother dopamine levels to lessen motor fluctuations.
  • Early‑stage Parkinson's disease: helps maintain functional mobility and delay progression of motor complications.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, replenishing deficient central dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism, extending its plasma half‑life, and enhancing clinical efficacy.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Dyskinesia: involuntary movements, especially at higher doses.
  • Insomnia: difficulty sleeping.
  • Dry mouth: reduced salivation.
  • Constipation: slowed bowel movements.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Severe depression or suicidal thoughts.
  • Hallucinations or psychosis.
  • Severe arrhythmias: irregular heart rhythm.
  • Hepatic dysfunction: elevated liver enzymes.
  • Anaphylactic reaction: rare allergic response.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially in the elderly.
  • Psychiatric assessment: monitor for hallucinations, depression, or suicidal ideation.
  • Renal function: dose may need adjustment in severe renal impairment.
  • Abrupt discontinuation: avoid sudden stop to prevent withdrawal and worsening symptoms.
  • Elderly patients: start at low dose and titrate slowly.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may mask Parkinsonian symptoms.
  • High‑dose pyridoxine (vitamin B6): reduces levodopa efficacy.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Antihypertensive drugs: additive blood pressure lowering.
  • Iron or calcium supplements: may decrease levodopa absorption; separate dosing times.

Frequently Asked Questions

Levodopa + Carbidopa + Entacapona Pentafarma is a prescription combination used to treat Parkinson's disease. It helps improve motor symptoms, reduces OFF periods, and provides more consistent dopamine levels in the brain.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmitter levels. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing physician based on the patient’s clinical condition, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Levodopa/Carbidopa/Entacapone in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects and increases central availability, while entacapone further prolongs levodopa’s half‑life. This triple combination often provides better control of motor fluctuations than single‑component regimens.

Store the tablets at room temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the package is tightly closed to maintain stability.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing with meals can help reduce gastrointestinal side effects. Follow the prescriber’s instructions regarding timing and any dose adjustments.

Serious risks include neuroleptic malignant syndrome, severe depression or suicidal thoughts, hallucinations, and rare severe allergic reactions. Patients should be monitored closely for any sudden changes in mood, behavior, or unexplained fever.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid this product. It is also contraindicated in individuals taking non‑selective MAO inhibitors or those with a history of severe neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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