Product image of Levodopa + Carbidopa + Entacapona Ratiopharm (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa + Carbidopa + Entacapona Ratiopharm

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa + Carbidopa + Entacapona Ratiopharm (Carbidopa, Entacapone, Levodopa)

Levodopa, Carbidopa, Entacapone, the active ingredient in Levodopa + Carbidopa + Entacapone Ratiopharm, is a dopamine precursor and COMT inhibitor combination presented as oral tablets for oral use. It treats Parkinson's disease and motor fluctuations in patients with Parkinson's disease, providing continuous dopaminergic stimulation and improving motor control.

GNH India supplies Levodopa + Carbidopa + Entacapone Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm-Comercio E Industria De Produtos Farmaceuticos Lda

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease, targeting dopaminergic pathways to improve motor function.

  • Parkinson's disease: improves overall motor symptoms and rigidity.
  • Motor fluctuations in Parkinson's disease: reduces OFF periods and smooths response to levodopa.
  • Advanced Parkinson's disease: enhances dopaminergic stimulation for better daily functioning.

How It Works

  • Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and prolonging its plasma half‑life, resulting in more stable dopaminergic stimulation.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: especially on standing, due to orthostatic changes.
  • Dry mouth: reduced salivation.
  • Headache: transient cranial discomfort.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Vomiting: occasional severe nausea leading to emesis.

Serious or Rare Side Effects

  • Dyskinesia: involuntary movements with prolonged use.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Depression or suicidal thoughts: mood changes requiring monitoring.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should observe several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension, especially after dose initiation.
  • Assess liver function: entacapone may affect hepatic enzymes; periodic testing is advised.
  • Evaluate psychiatric status: risk of hallucinations or mood changes in susceptible patients.
  • Adjust dose in renal impairment: use caution and consider dose reduction.
  • Avoid use in patients with known hypersensitivity to any component.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • MAO‑B inhibitors: risk of hypertensive crisis.
  • Non‑selective MAO inhibitors: severe hypertension may occur.
  • Iron supplements: reduce levodopa absorption, diminishing efficacy.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may mask levodopa side effects.
  • Antidepressants (SSRIs, SNRIs): increase risk of serotonin syndrome.
  • Antihypertensive drugs: additive blood‑pressure lowering effect.

Frequently Asked Questions

Levodopa + Carbidopa + Entacapone is prescribed to manage Parkinson's disease and to reduce motor fluctuations in patients who experience periods of reduced symptom control, known as OFF episodes. It works by increasing dopamine levels in the brain and prolonging the effect of levodopa.

Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted to dopamine. Carbidopa blocks peripheral conversion of levodopa, allowing more to reach the brain. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown outside the brain, which extends its therapeutic action.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s disease stage, response to therapy, and other medical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for use in pregnancy and lactation are limited, and the product’s pregnancy category is unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levodopa/Carbidopa/Entacapone combines a dopamine precursor with a peripheral decarboxylase inhibitor and a COMT inhibitor, offering more stable levodopa levels than levodopa alone. Compared with other formulations, it may reduce OFF time and improve motor control without requiring additional dosing frequency.

The tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep them out of reach of children and do not use them after the expiration date.

The medication is taken orally, usually with food or as directed by the prescriber to minimize gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include dyskinesia (involuntary movements), severe hypotension, hallucinations, neuroleptic malignant syndrome, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for these events, and any concerning symptoms should be reported promptly.

Individuals with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid this medication. It is also contraindicated in patients taking non‑selective MAO inhibitors or those with severe hepatic impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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