Product image of Levodopa + Carbidopa + Entacapona Tecnigen (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa + Carbidopa + Entacapona Tecnigen

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa + Carbidopa + Entacapona Tecnigen (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa + Carbidopa + Entacapone Tecnigen, is an antiparkinson agent presented as an oral tablet for oral use. It treats the motor symptoms of Parkinson's disease in adults.

GNH India supplies Levodopa + Carbidopa + Entacapone Tecnigen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Verum Pharma- Produtos Farmacêuticos, Unipessoal, Lda.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease and related motor fluctuations.

  • Parkinson's disease: improves overall motor control and reduces rigidity and bradykinesia.
  • Motor fluctuations (wearing‑off): shortens OFF periods and extends ON time.
  • Advanced Parkinson's disease: enhances the effectiveness of levodopa therapy when monotherapy is insufficient.

How It Works

  • Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted to dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, increasing central levodopa availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and prolonging its plasma half‑life, together providing more stable dopaminergic stimulation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dyskinesia: involuntary movements, especially at higher doses.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Hallucinations or psychosis: visual or auditory disturbances.
  • Severe depression or suicidal thoughts.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, clinicians should consider patient‑specific factors and monitor for adverse events.

  • Cardiovascular disease: monitor blood pressure and heart rate due to orthostatic effects.
  • Liver function: assess baseline enzymes as entacapone is hepatically metabolised.
  • Psychiatric history: watch for hallucinations, confusion, or mood changes.
  • Pregnancy and lactation: safety unknown; use only if potential benefit justifies risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone may interact with several drug classes; careful review is required.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish antiparkinson efficacy.
  • Iron or calcium supplements: reduce levodopa absorption if taken simultaneously.

Moderate Interactions (Monitor Closely)

  • Selective MAO‑B inhibitors: may increase dopaminergic activity.
  • Antihypertensive agents: additive blood‑pressure lowering effect.
  • Carbamazepine and other enzyme inducers: may lower plasma levels of entacapone.
  • SSRIs or SNRIs: monitor for serotonin syndrome, though risk is low.

Frequently Asked Questions

Levodopa + Carbidopa + Entacapone is prescribed to manage the motor symptoms of Parkinson's disease, especially in patients who experience fluctuations in symptom control (wearing‑off). It helps improve movement, reduce rigidity, and extend periods of good motor function.

Levodopa serves as a dopamine precursor that crosses into the brain and is converted to dopamine. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and prolonging its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects, and entacapone extends levodopa’s half‑life, providing more stable symptom control. It is often preferred over immediate‑release levodopa when patients experience wearing‑off, but individual choice depends on clinical response and tolerability.

The product should be stored at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain stability and potency.

It is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional. Dosing times are often aligned with meals to optimise absorption and reduce gastrointestinal upset.

Serious risks include severe allergic reactions, neuroleptic malignant syndrome, profound hallucinations or psychosis, severe depression with suicidal thoughts, and cardiac arrhythmias. Patients should be monitored closely for any of these events, and treatment should be discontinued immediately if they occur.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors. Caution is advised for those with severe cardiovascular disease, liver impairment, or a history of psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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