Product image of Levodopa/Carbidopa/Entacapone Abz (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Abz

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Abz (Carbidopa, Entacapone, Levodopa)

Levodopa, Carbidopa, Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Abz, is a combination dopamine precursor and COMT inhibitor presented as a tablet for oral use. It treats Parkinson's disease and Parkinson's disease with motor fluctuations.

GNH India supplies Levodopa/Carbidopa/Entacapone Abz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinsonian disorders and related motor complications.

  • Parkinson's disease: improves overall motor symptoms such as bradykinesia, rigidity and tremor.
  • Parkinson's disease with motor fluctuations: reduces "off" periods and prolongs "on" time without troublesome dyskinesia.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, increasing the amount of levodopa that reaches the brain. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing peripheral levodopa metabolism and extending its plasma half‑life, thereby enhancing and prolonging dopaminergic stimulation.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Dry mouth: reduced salivation.
  • Insomnia: difficulty falling or staying asleep.
  • Orthostatic hypotension: drop in blood pressure on standing.
  • Vomiting: occasional severe nausea.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: marked blood‑pressure fall requiring medical attention.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe depression or suicidal thoughts.
  • Allergic reactions: rash, angioedema, or anaphylaxis.

Precautions & Warnings

Before prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially at therapy initiation.
  • Psychiatric assessment: evaluate for hallucinations, confusion, or depression.
  • Renal/hepatic function: dose may need adjustment in impairment.
  • Cardiovascular disease: use caution in patients with arrhythmias or ischemic heart disease.
  • Abrupt discontinuation: taper gradually to avoid withdrawal symptoms.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Selective MAO‑B inhibitors (e.g., selegiline): may cause severe hypertension.
  • Antipsychotics (e.g., haloperidol): can diminish antiparkinson effect.
  • Iron or antacid preparations: reduce levodopa absorption.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: may increase risk of serotonin syndrome.
  • Tricyclic antidepressants: may enhance orthostatic hypotension.
  • Diuretics: additive blood‑pressure lowering effect.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone Abz is prescribed to manage the motor symptoms of Parkinson's disease and to reduce motor fluctuations such as "off" periods in patients whose disease has progressed despite levodopa monotherapy.

Levodopa is converted to dopamine in the brain, carbidopa blocks peripheral conversion of levodopa to dopamine, increasing central availability, and entacapone inhibits the COMT enzyme, slowing peripheral levodopa breakdown and extending its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing physician based on the individual patient's disease severity, response to therapy, and tolerability. Patients should follow the prescriber's instructions precisely.

Safety data in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects and increases central availability, while entacapone further prolongs levodopa's action by inhibiting COMT. This combination often provides smoother symptom control and fewer "off" periods.

Levodopa/Carbidopa/Entacapone Abz should be stored at room temperature, below 25 °C, in its original packaging, protected from moisture and direct light to maintain stability.

The medication is taken orally, usually with food or a light snack to reduce gastrointestinal irritation. Tablets should be swallowed whole with a full glass of water unless otherwise directed by the prescriber.

Serious adverse events can include dyskinesia, hallucinations, severe hypotension, neuroleptic malignant syndrome, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for these signs, especially during treatment initiation or dose changes.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid this medication. It is also contraindicated in individuals taking non‑selective MAO inhibitors or those with a history of severe cardiovascular disease without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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