Product image of Levodopa/Carbidopa/Entacapone Biogaran (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Biogaran

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Biogaran (Carbidopa, Entacapone, Levodopa)

Levodopa, Carbidopa, Entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Biogaran, are an antiparkinson agent presented as an oral tablet for oral use. The combination is prescribed to manage Parkinson's disease symptoms by enhancing central dopamine levels. It is indicated for patients with fluctuating motor response who require more stable dopaminergic stimulation.

GNH India supplies Levodopa/Carbidopa/Entacapone Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier, providing quality‑assured medication to hospitals, pharmacies and clinics worldwide, with adherence to EU GMP standards and robust logistics for timely delivery.

Manufacturer / TM Owner

Biogaran

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is an antiparkinson combination used to manage motor symptoms in Parkinson's disease.

  • Parkinson's disease (motor fluctuations): reduces OFF time and increases ON time with more stable symptom control.
  • Parkinson's disease (early adjunct therapy): enhances levodopa efficacy when added to existing regimen.
  • Parkinson's disease (advanced disease): provides sustained dopaminergic stimulation to improve daily motor function.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine. Carbidopa inhibits peripheral dopa decarboxylase, preventing premature conversion and increasing central levodopa availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism, thereby prolonging its plasma half‑life and enhancing dopaminergic stimulation in the brain.

Side Effects

Adverse reactions may occur with any antiparkinson therapy and should be monitored.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness or light‑headedness
  • Headache
  • Orthostatic hypotension
  • Insomnia

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Cardiac arrhythmias
  • Neuroleptic malignant‑like syndrome
  • Severe psychiatric disturbances (hallucinations, psychosis)
  • Dyskinesia
  • Allergic reactions including rash or angioedema

Precautions & Warnings

Use of Levodopa/Carbidopa/Entacapone requires careful clinical monitoring.

  • Monitor blood pressure: watch for orthostatic hypotension, especially at treatment initiation.
  • Assess psychiatric status: risk of hallucinations, confusion, or worsening psychosis.
  • Evaluate liver function: entacapone may affect hepatic enzymes; periodic testing is advised.
  • Adjust dose in renal impairment: consider reduced clearance and potential accumulation.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes; clinicians should review patient medication lists.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may exacerbate confusion and cognitive decline.
  • CNS depressants: increase sedation and dizziness.
  • High‑protein meals: reduce levodopa absorption and efficacy.
  • Iron or mineral supplements: chelate levodopa and diminish its bioavailability.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): possible serotonin syndrome.
  • Antihypertensives: additive blood‑pressure lowering effects.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic response.
  • CYP2C9 inhibitors (e.g., fluconazole): raise entacapone plasma levels.
  • Diuretics: may alter electrolyte balance and affect blood‑pressure control.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone Biogaran is prescribed to treat Parkinson's disease, specifically to improve motor control and reduce OFF periods in patients experiencing fluctuations in symptom control while on levodopa therapy.

The formulation combines levodopa, which is converted to dopamine in the brain, with carbidopa, which blocks peripheral conversion, and entacapone, which inhibits the COMT enzyme. This trio increases the amount of dopamine reaching the central nervous system and prolongs its action, providing more consistent symptom relief.

Dosage is individualized and determined by the prescribing clinician based on the patient’s disease stage, response to therapy, and tolerability. The prescriber will select the appropriate strength and dosing schedule to achieve optimal motor control.

Safety data in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare professional.

Enquiries can be submitted via the product page on gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with levodopa/carbidopa alone, the addition of entacapone in this combination slows levodopa metabolism, extending its plasma half‑life. This often results in reduced dosing frequency, fewer OFF periods, and improved overall motor stability for many patients.

The tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Levodopa/Carbidopa/Entacapone is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals can help maintain stable drug levels. Follow the prescribing clinician’s instructions for timing and frequency.

Serious risks include severe hypotension, cardiac arrhythmias, neuroleptic malignant‑like syndrome, marked psychiatric disturbances such as hallucinations or psychosis, and severe allergic reactions. Patients should be monitored closely for these events, especially during treatment initiation or dose changes.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid this medication. It is also contraindicated in individuals taking non‑selective MAO inhibitors, and caution is advised in those with severe cardiovascular disease, hepatic impairment, or a history of malignant neuroleptic syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Carbidopa, Entacapone, Levodopa

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT