Product image of Levodopa/Carbidopa/Entacapone G.L. Pharma (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa/Entacapone G.L. Pharma

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa/Entacapone G.L. Pharma (Entacapone, Levodopa, Carbidopa Monohydrate)

Levodopa, Carbidopa, Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone G.L. Pharma, is an Antiparkinson agent presented as an oral tablet for oral use. It treats Parkinson's disease and associated motor fluctuations in adult patients.

GNH India supplies Levodopa/Carbidopa/Entacapone G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinsonian disorders and related motor complications.

  • Parkinson's disease: improves overall motor function by increasing central dopamine levels.
  • Motor fluctuations in Parkinson's disease: reduces OFF periods and extends ON time.
  • Levodopa‑responsive Parkinsonian syndrome: provides more stable symptom control when combined with other antiparkinson agents.

How It Works

  • Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted to dopamine in the CNS. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and prolonging its therapeutic effect.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Insomnia or vivid dreams
  • Dyskinesia (involuntary movements)
  • Dry mouth

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Neuroleptic malignant syndrome
  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Hyperpyrexia or severe fever
  • Suicidal ideation or severe depression
  • Hallucinations or psychosis

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: watch for orthostatic drops, especially after dose changes.
  • Psychiatric assessment: evaluate for depression, hallucinations, or suicidal thoughts.
  • Renal/hepatic function: adjust dosing in patients with impairment.
  • Cardiac disease: use caution in patients with arrhythmias or ischemic heart disease.
  • Discontinuation: avoid abrupt cessation to reduce risk of withdrawal dyskinesia.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Other COMT inhibitors: may cause excessive levodopa levels.
  • Antipsychotics that block dopamine receptors: reduce therapeutic efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive blood‑pressure lowering effect.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome.
  • Iron or vitamin C supplements: can impair levodopa absorption if taken simultaneously.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage Parkinson's disease and to reduce motor fluctuations such as OFF periods in patients who respond to levodopa therapy. It helps improve overall motor control and prolongs the duration of symptom relief.

The combination works by delivering levodopa, a dopamine precursor, while carbidopa blocks its peripheral conversion, increasing brain availability. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown outside the brain, which extends its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and other medical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with levodopa alone, the addition of carbidopa and entacapone reduces peripheral metabolism, leading to more stable plasma levels and fewer OFF periods. It offers advantages over other COMT inhibitors by combining three agents in a single tablet, simplifying dosing.

Store the tablets at room temperature, below 25 °C, in the original container. Keep them away from moisture, heat, and direct sunlight. Do not use if the packaging is damaged or the tablets appear discolored.

The medication is taken orally, usually with food to reduce gastrointestinal irritation. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include severe hypotension, neuroleptic malignant syndrome, allergic reactions such as anaphylaxis, hyperpyrexia, and psychiatric complications like severe depression or suicidal thoughts. Patients should be monitored closely for these events.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors or other COMT inhibitors due to the risk of excessive levodopa exposure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Entacapone, Levodopa, Carbidopa Monohydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT