Product image of Levodopa/Carbidopa/Entacapone Lannacher (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa/Entacapone Lannacher

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa/Entacapone Lannacher (Entacapone, Levodopa, Carbidopa Monohydrate)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Lannacher, is an antiparkinson agent presented as an oral tablet for oral use. It is used to manage the motor symptoms of Parkinson's disease in adults.

GNH India supplies Levodopa/Carbidopa/Entacapone Lannacher as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

  • Levodopa/Carbidopa/Entacapone is an antiparkinson combination that targets dopamine deficiency in Parkinson's disease.
  • Parkinson's disease: improves motor symptoms and reduces "off" periods.
  • Parkinson's disease with motor fluctuations: prolongs the clinical effect of levodopa.
  • Advanced Parkinson's disease: helps maintain functional mobility and daily activities.

How It Works

  • Levodopa is absorbed and crosses the blood‑brain barrier where it is decarboxylated to dopamine, replenishing central dopamine stores. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its availability to the brain. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its plasma half‑life, thereby enhancing and prolonging dopaminergic stimulation.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Orthostatic hypotension
  • Dyskinesia (involuntary movements)
  • Dry mouth
  • Insomnia or vivid dreams
  • Diarrhea or abdominal discomfort

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Severe hypertension or hypertensive crisis
  • Cardiac arrhythmias
  • Severe liver enzyme elevation
  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Psychiatric disturbances including hallucinations or confusion

Precautions & Warnings

  • Levodopa/Carbidopa/Entacapone requires careful monitoring due to its pharmacologic profile.
  • Dose adjustments: titrate gradually to balance symptom control and side‑effects.
  • Cardiovascular monitoring: watch for orthostatic hypotension and hypertension.
  • Psychiatric assessment: monitor for hallucinations, confusion, or mood changes.
  • Renal or hepatic impairment: consider dose modification or increased surveillance.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several drug classes that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics with strong dopamine blockade: may diminish therapeutic effect.
  • High‑dose vitamin B6 (pyridoxine): can reduce levodopa availability.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may exacerbate orthostatic hypotension.
  • Iron or calcium supplements: can impair levodopa absorption; separate dosing by at least 2 hours.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage motor symptoms and reduce fluctuations in patients with Parkinson's disease. It combines three agents that increase dopamine availability in the brain, helping improve movement control and daily functioning.

Levodopa is converted to dopamine in the brain, while carbidopa blocks its peripheral conversion, increasing central delivery. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown outside the brain, which prolongs its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s disease stage, response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data are limited, and the product is classified as pregnancy category unknown. It should only be used during pregnancy or lactation if the potential benefit outweighs the possible risk, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Standard levodopa alone is rapidly metabolized, leading to motor fluctuations. Adding carbidopa reduces peripheral conversion, and entacapone further inhibits COMT metabolism, resulting in more stable plasma levels, longer “on” periods, and fewer dosing adjustments compared with levodopa monotherapy.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

The medication is taken orally, usually with food to reduce gastrointestinal irritation. Tablets should be swallowed whole with a full glass of water, and dosing times should be spaced evenly as directed by the prescriber.

Serious risks include neuroleptic malignant syndrome, severe hypertension, cardiac arrhythmias, liver enzyme elevations, and psychiatric disturbances such as hallucinations or confusion. Patients should seek immediate medical attention if any of these events occur.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors and in those with uncontrolled narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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