Product image of Levodopa+carbidopa+entacapone Mylan (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa+carbidopa+entacapone Mylan

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa+carbidopa+entacapone Mylan (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone, the active ingredient in Levodopa+carbidopa+entacapone Mylan, is a Levodopa/Carbidopa/Entacapone combination presented as an oral tablet for oral use. It is prescribed to manage Parkinson's disease symptoms in adults by enhancing dopaminergic activity in the brain, helping reduce motor fluctuations and improve quality of life.

GNH India supplies Levodopa+carbidopa+entacapone Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance, reliable logistics for consistent patient access across diverse markets, and adhering to international pharmacopeial standards.

Manufacturer / TM Owner

Mylan Pharmaceuticals Limited

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used as an adjunct therapy in the dopaminergic treatment pathway for Parkinson's disease.

  • Parkinson's disease: improves overall motor control and reduces OFF periods.
  • Motor fluctuations in Parkinson's disease: prolongs levodopa effect to smooth symptom control.
  • Wearing‑off phenomenon: enhances dopaminergic stimulation to lessen symptom recurrence.
  • Adjunct to levodopa therapy: allows lower levodopa doses while maintaining efficacy.

How It Works

  • The combination delivers levodopa, a dopamine precursor, while carbidopa blocks peripheral aromatic L‑amino acid decarboxylase, increasing central levodopa availability. Entacapone inhibits catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its plasma half‑life, thereby sustaining dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Headache: transient and usually self‑limiting.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure decline requiring medical attention.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe liver dysfunction: elevated enzymes or hepatic failure.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Suicidal ideation: emergent mood changes needing urgent evaluation.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety aspects.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution; assess liver enzymes regularly.
  • Cardiovascular disease: observe for hypotensive episodes, especially in the elderly.
  • Psychiatric history: watch for hallucinations, confusion, or mood changes.
  • Concomitant MAO‑B inhibitors: avoid due to risk of hypertensive crisis.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic drugs: may mask Parkinsonian symptoms.
  • Antihypertensive agents: additive blood‑pressure lowering effect.

Moderate Interactions (Monitor Closely)

  • Other dopaminergic agents (e.g., dopamine agonists): may increase dyskinesia.
  • CYP2C9 inhibitors (e.g., fluconazole): may raise entacapone levels.
  • High‑protein meals: can reduce levodopa absorption and diminish efficacy.

Frequently Asked Questions

Levodopa+carbidopa+entacapone Mylan is an oral combination medication used to treat Parkinson's disease. It works by enhancing dopamine levels in the brain, helping to control motor symptoms such as tremor, rigidity, and bradykinesia, and reducing periods when medication effects wear off.

The formulation delivers levodopa, a dopamine precursor, while carbidopa blocks its peripheral conversion, increasing central availability. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its half‑life, which together provide more stable dopaminergic stimulation for Parkinson's patients.

The appropriate dose is determined individually by a qualified prescriber based on disease severity, patient response, and tolerability. Healthcare professionals adjust the regimen to achieve optimal symptom control while minimizing side effects, and patients should follow the prescribed instructions exactly.

Safety data for use in pregnancy and lactation are limited, and the product is generally classified as contraindicated or to be used only if the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects, and entacapone prolongs levodopa’s action, allowing more consistent symptom control. It offers an advantage over single‑component regimens by decreasing OFF periods and potentially allowing lower levodopa doses, though individual response varies.

Levodopa+carbidopa+entacapone Mylan tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the medication out of reach of children and do not use after the expiry date printed on the package.

The medication is taken orally, usually with food to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include severe hypotension, neuroleptic malignant syndrome, significant liver dysfunction, and rare psychiatric events such as suicidal thoughts. Patients should be monitored closely for these signs, and any sudden changes in blood pressure, mood, or liver function should prompt immediate medical evaluation.

The product is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients. It should also be avoided in individuals taking non‑selective MAO inhibitors or those with a history of severe cardiovascular instability unless under specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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