Product image of Levodopa/Carbidopa/Entacapone Orion (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Orion

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Orion (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Orion, is an antiparkinson agent presented as an oral tablet for oral use. It treats Parkinson's disease and motor fluctuations in adult patients.
GNH India supplies Levodopa/Carbidopa/Entacapone Orion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinsonian disorders and related motor complications.

  • Parkinson's disease: improves overall motor function and reduces rigidity and bradykinesia.
  • Parkinson's disease with motor fluctuations: decreases OFF periods and prolongs ON time.
  • Early‑stage Parkinson's disease: enhances central dopamine availability to support symptom control.

How It Works

  • Levodopa is a precursor that crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism, extending its plasma half‑life and sustaining dopaminergic activity.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: transient light‑headedness, especially on standing.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dyskinesia: involuntary movements with prolonged use.
  • Insomnia: difficulty falling or staying asleep.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening hyperthermia and rigidity.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Hallucinations or psychosis: visual or auditory disturbances.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Cardiovascular monitoring: assess blood pressure and heart rate regularly.
  • Psychiatric evaluation: watch for hallucinations, confusion, or mood changes.
  • Renal and hepatic function: adjust use if severe impairment is present.
  • Concomitant MAO‑B inhibitors: avoid or separate dosing by at least 14 days.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Storage: Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several drug classes that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may diminish dopaminergic response.
  • High‑dose pyridoxine (vitamin B6): accelerates peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may potentiate orthostatic hypotension.
  • Iron or antacids: can reduce levodopa absorption; separate administration by at least 2 hours.
  • SSRIs or SNRIs: monitor for serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage Parkinson's disease and to reduce motor fluctuations such as OFF periods. It works by increasing dopamine levels in the brain, helping to improve movement control and reduce rigidity and tremor.

Levodopa serves as a dopamine precursor that crosses the blood‑brain barrier. Carbidopa blocks peripheral conversion of levodopa, allowing more to reach the brain. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing physician based on the individual’s disease stage, response to therapy, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety in pregnancy and lactation has not been fully established. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with levodopa alone, the combination adds carbidopa to increase central availability and entacapone to prolong the drug’s half‑life, resulting in more stable symptom control and fewer dosing intervals. It is often preferred when patients experience motor fluctuations on standard levodopa therapy.

Store the tablets at temperatures below 25 °C in their original packaging. Protect them from moisture, light, and excessive heat to maintain stability and potency throughout the shelf life.

The medication is taken orally, usually with food to reduce gastrointestinal irritation. Tablets should be swallowed whole with a full glass of water, and dosing times should be spaced as directed by the prescriber to maintain consistent plasma levels.

Serious risks include neuroleptic malignant syndrome, severe hypotension, cardiac arrhythmias, hallucinations or psychosis, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any formulation components should avoid this medication. It is also contraindicated in individuals taking non‑selective MAO inhibitors or those with uncontrolled narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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