Product image of Levodopa/Carbidopa/Entacapone Pharmexon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa/Entacapone Pharmexon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa/Entacapone Pharmexon (Entacapone, Levodopa, Carbidopa Monohydrate)

Levodopa, Carbidopa, and Entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Pharmexon, are antiparkinson agents presented as an oral combination tablet for oral use. They treat Parkinson's disease in adults by restoring dopaminergic activity in the brain.

GNH India supplies Levodopa/Carbidopa/Entacapone Pharmexon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease and related motor complications.

  • Parkinson's disease: improves overall motor function and reduces rigidity.
  • Parkinson's disease with motor fluctuations: shortens OFF periods and smooths symptom control.
  • Parkinson's disease (adjunct therapy): enhances the central availability of levodopa, allowing lower levodopa doses.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, replenishing deficient neurotransmitter levels. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central delivery. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism and extending its plasma half‑life, thereby enhancing and prolonging dopaminergic stimulation.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Dyskinesia (involuntary movements)
  • Orthostatic hypotension
  • Dizziness
  • Insomnia

Serious or Rare Side Effects

  • Severe liver injury
  • Neuroleptic malignant syndrome
  • Anaphylactic or severe allergic reactions
  • Agranulocytosis
  • Hyperthermia
  • Suicidal ideation or severe psychiatric changes

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Monitor blood pressure: risk of orthostatic hypotension.
  • Assess hepatic function: entacapone may affect liver enzymes.
  • Evaluate for psychiatric symptoms: possible hallucinations or confusion.
  • Adjust dose in renal impairment: use caution and monitor renal function.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several drug classes that may require dose adjustment or monitoring.

Major Interactions (Avoid)

  • MAO‑B inhibitors: risk of hypertensive crisis.
  • Non‑selective MAO inhibitors: can precipitate severe hypertension.
  • Anticholinergics: may increase confusion and cognitive impairment.

Moderate Interactions (Monitor Closely)

  • SSRIs and SNRIs: monitor for serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage Parkinson's disease, particularly to improve motor symptoms and reduce OFF periods when used as part of a levodopa‑based regimen.

Levodopa is converted to dopamine in the brain; Carbidopa blocks peripheral conversion, increasing central levodopa levels; Entacapone inhibits COMT, prolonging levodopa’s plasma half‑life and enhancing its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s individual condition, response, and tolerability.

Safety data are limited; the medication should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and this decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with levodopa alone, the combination adds Carbidopa to reduce peripheral metabolism and Entacapone to inhibit COMT, resulting in more stable plasma levels, fewer dose fluctuations, and often a reduced need for higher levodopa doses.

Store at room temperature, below 25 °C, in the original packaging, and protect from moisture and direct sunlight to maintain product stability.

The medication is taken orally, usually with food or as directed by the prescribing physician, to ensure consistent absorption and to minimize gastrointestinal irritation.

Serious risks include severe liver injury, neuroleptic malignant syndrome, life‑threatening allergic reactions, agranulocytosis, hyperthermia, and significant psychiatric changes such as suicidal thoughts.

Patients with known hypersensitivity to any component, those taking non‑selective MAO inhibitors, or individuals with severe hepatic impairment should avoid this medication unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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