Product image of Levodopa/Carbidopa/Entacapone Rivopharm (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Rivopharm

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Rivopharm (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Rivopharm, is an antiparkinson agent presented as an oral tablet for oral use. It treats Parkinson's disease and motor fluctuations in patients with Parkinson's disease.

GNH India supplies Levodopa/Carbidopa/Entacapone Rivopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rivopharm Ltd

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson’s disease and related motor complications.

  • Parkinson's disease: improves motor symptoms by increasing central dopamine levels.
  • Motor fluctuations in Parkinson's disease: reduces "off" time and smooths response to therapy.
  • Early-stage Parkinson's disease adjunct: used as part of initial therapy to delay symptom progression.

How It Works

  • Levodopa is absorbed and crosses the blood‑brain barrier, where it is decarboxylated to dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), prolonging levodopa plasma half‑life and enhancing dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dyskinesia: involuntary movements, often dose‑related.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and rigidity.
  • Severe depression or suicidal thoughts: may emerge or worsen.
  • Cardiac arrhythmias: uncommon but possible, especially with pre‑existing heart disease.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Renal impairment: dose may need adjustment; monitor renal function.
  • Hepatic disease: use with caution; liver function tests recommended.
  • History of melanoma or skin cancer: monitor for new lesions.
  • Concomitant MAO‑B inhibitors: avoid concurrent use to prevent hypertensive crisis.
  • Pregnancy and breastfeeding: safety not established; weigh risks and benefits.
  • Store at ambient temperature: keep below 25 °C, protect from moisture in original container.

Avoid Interactions

Levodopa/Carbidopa/Entacapone interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may diminish antiparkinson effect.
  • High‑dose pyridoxine (vitamin B6): reduces levodopa conversion.

Moderate Interactions (Monitor Closely)

  • Iron or calcium supplements: decrease levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensive agents: additive blood pressure lowering.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage the motor symptoms of Parkinson's disease and to reduce motor fluctuations, such as "off" periods, that can occur in patients receiving levodopa therapy.

The combination delivers levodopa, which is converted to dopamine in the brain, while carbidopa blocks peripheral conversion of levodopa, increasing its central availability. Entacapone inhibits the COMT enzyme, extending levodopa’s plasma half‑life and enhancing dopaminergic stimulation.

The dose of Levodopa/Carbidopa/Entacapone is individualized by the prescribing clinician based on the patient's disease stage, response to therapy, and tolerability. The prescriber determines the appropriate strength and dosing schedule.

Safety of Levodopa/Carbidopa/Entacapone in pregnancy and lactation has not been established. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects and increases central levodopa levels, while entacapone further prolongs levodopa’s action. This triple combination can provide smoother symptom control than single‑component regimens, though individual response varies.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

Levodopa/Carbidopa/Entacapone is taken orally, usually with food or a light snack to reduce gastrointestinal irritation. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe depression or suicidal ideation, and cardiac arrhythmias. Patients should be monitored for sudden changes in mood, unexplained fever, muscle rigidity, or irregular heartbeats and seek immediate medical attention if they occur.

The medication is contraindicated in individuals with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients, as well as patients taking non‑selective MAO inhibitors. Caution is also advised for those with severe hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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