Product image of Levodopa/Carbidopa/Entacapone Stada (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Stada

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Stada (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, and entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Stada, are an antiparkinson agent presented as an oral tablet for oral use. The combination is employed to manage Parkinson's disease symptoms in adult patients. Levodopa is a dopamine precursor, carbidopa inhibits peripheral metabolism, and entacapone prolongs levodopa availability, together providing more consistent motor control.

GNH India supplies Levodopa/Carbidopa/Entacapone Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson’s disease, targeting motor fluctuations and overall symptom control.

  • Parkinson’s disease (early to advanced): improves motor function and reduces “off” periods.
  • Fluctuating Parkinson’s disease: provides smoother dopamine levels to lessen motor fluctuations.
  • Parkinson’s disease with wearing‑off: extends levodopa effect, decreasing dosing frequency.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, replenishing deficient central dopamine in Parkinson’s disease. Carbidopa inhibits peripheral aromatic L‑amino‑acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and prolonging its plasma half‑life, thereby enhancing and stabilizing dopaminergic stimulation. The combined action results in more consistent dopaminergic activity throughout the dosing interval.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Insomnia or vivid dreams
  • Dyskinesia (involuntary movements)
  • Constipation

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Neuroleptic malignant‑like syndrome
  • Hallucinations or severe psychosis
  • Major depression or suicidal ideation
  • Cardiac arrhythmias
  • Anaphylaxis or severe allergic reactions
  • Significant liver enzyme elevations

Precautions & Warnings

Before initiating therapy, clinicians should consider individual patient factors and monitor for specific safety concerns.

  • Dose adjustments: tailor dosing based on clinical response and tolerability.
  • Renal impairment: use with caution; monitor renal function.
  • Hepatic impairment: consider dose reduction; monitor liver enzymes.
  • Cardiovascular disease: monitor blood pressure and heart rate.
  • Pregnancy and lactation: safety not established; avoid unless essential.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Selective MAO‑B inhibitors (e.g., selegiline) combined with entacapone: may increase levodopa levels excessively.
  • Anticholinergics: may mask Parkinsonian symptoms.
  • Antipsychotics (dopamine antagonists): reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • SSRIs/SNRIs: may increase risk of serotonin syndrome.
  • Iron supplements: decrease levodopa absorption; separate dosing by at least 2 h.
  • Protein‑rich meals: may reduce levodopa bioavailability; advise timing.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone Stada is prescribed to treat Parkinson's disease. The combination helps increase dopamine levels in the brain, improving motor symptoms such as tremor, rigidity, and bradykinesia, and it also reduces the frequency of "off" periods that can occur with levodopa alone.

Levodopa is a precursor that is converted to dopamine in the central nervous system. Carbidopa blocks the peripheral enzyme that would otherwise convert levodopa before it reaches the brain, while entacapone inhibits the COMT enzyme, slowing levodopa breakdown. Together they provide more stable and higher dopamine concentrations in the brain.

The dose is individualized by the prescribing clinician based on the patient’s disease stage, response to therapy, and tolerability. Physicians start with a low dose and titrate upward as needed, following clinical guidelines and monitoring for side effects.

Safety data for Levodopa/Carbidopa/Entacapone during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Standard levodopa alone is rapidly metabolized, leading to fluctuations in plasma levels and motor symptoms. Adding carbidopa reduces peripheral conversion, and entacapone further prolongs levodopa’s half‑life by inhibiting COMT. This results in smoother dopamine delivery, fewer "off" periods, and often a lower total levodopa dose compared with levodopa monotherapy.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and light, and avoid storing in areas with high humidity or direct sunlight.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals can help maintain stable drug levels. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe hypotension, neuroleptic malignant‑like syndrome, marked hallucinations or psychosis, major depression with suicidal thoughts, cardiac arrhythmias, and severe allergic reactions such as anaphylaxis. Any sudden or severe symptoms should prompt immediate medical evaluation.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors, and caution is advised for those with uncontrolled cardiovascular disease, severe liver impairment, or a history of malignant neuroleptic syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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