Product image of Levodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Teva

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, and entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Teva, are antiparkinson agents presented as tablets for oral use. They treat Parkinson's disease by improving motor function in adult patients.

GNH India supplies Levodopa/Carbidopa/Entacapone Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is an oral antiparkinson combination that targets motor fluctuations in Parkinson's disease.

  • Parkinson's disease (early stage): enhances levodopa response and improves daily motor activities.
  • Parkinson's disease (advanced stage): reduces OFF periods and stabilises symptom control.
  • Parkinson's disease (wearing‑off phenomenon): prolongs levodopa plasma half‑life, decreasing the frequency of motor fluctuations.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism and extending its plasma half‑life, thereby enhancing clinical efficacy.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Headache
  • Insomnia

Serious or Rare Side Effects

  • Dyskinesia (involuntary movements)
  • Hallucinations or psychosis
  • Severe hypotension or syncope
  • Cardiac arrhythmias
  • Neuroleptic malignant syndrome
  • Hepatic dysfunction (rare).

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution; assess liver enzymes regularly.
  • Cardiovascular disease: observe blood pressure and heart rate for hypotensive episodes.
  • Psychiatric history: watch for hallucinations, confusion, or mood changes.
  • Concomitant MAO‑B inhibitors: avoid co‑administration due to risk of hypertensive crisis.
  • Pregnancy: safety unknown; prescribe only if potential benefit justifies the risk.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several medicines; categorise the risk level.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may precipitate hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): can diminish antiparkinson efficacy.
  • Anticholinergic agents: may mask motor symptom changes.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: increase risk of serotonin syndrome.
  • Diuretics: may exacerbate orthostatic hypotension.
  • Antihypertensive drugs: may potentiate blood‑pressure‑lowering effects.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage Parkinson's disease. It improves motor symptoms, reduces OFF periods, and helps control the wearing‑off phenomenon that can occur with levodopa monotherapy.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its central availability, while entacapone inhibits COMT, extending levodopa’s plasma half‑life and enhancing its therapeutic effect.

The dosage regimen is individualized. A qualified prescriber determines the appropriate dose and schedule based on the patient’s clinical status, response to therapy, and tolerability.

Safety data in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Adding entacapone to levodopa/carbidopa prolongs levodopa’s half‑life by inhibiting COMT, which can reduce dosing frequency and improve control of motor fluctuations compared with levodopa/carbidopa alone.

Store tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect from moisture, heat and direct sunlight to maintain product stability.

The medication is taken orally as a tablet, usually with a small amount of food or water. Patients should follow the prescriber’s instructions regarding timing relative to meals, as food can affect levodopa absorption.

Serious adverse events include dyskinesia, severe hypotension, hallucinations or other psychiatric disturbances, and rare hepatic dysfunction. Prompt medical attention is required if any of these symptoms develop.

Patients with known hypersensitivity to any component, those with narrow‑angle glaucoma, severe hepatic impairment, or uncontrolled cardiovascular disease should avoid this medication unless a physician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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