Product image of Levodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapone Teva

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, and entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Teva, are an antiparkinson agent presented as an oral tablet for oral use. It treats Parkinson's disease and motor fluctuations in adults.

GNH India supplies Levodopa/Carbidopa/Entacapone Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinsonian disorders, addressing dopamine deficiency and motor fluctuations.

  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity, and tremor.
  • Parkinson's disease motor fluctuations: reduces "off" periods and prolongs "on" time.
  • Secondary Parkinsonism: helps control symptoms when Parkinsonism is due to other neurological conditions.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring central dopamine levels. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its therapeutic effect.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Insomnia: difficulty falling or staying asleep.
  • Hallucinations: visual disturbances, especially in older patients.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Severe hypotension: may lead to fainting or shock.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Psychiatric disturbances: severe agitation or psychosis.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible individuals.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Dose adjustment: required in renal or hepatic impairment to avoid accumulation.
  • Monitor blood pressure: risk of orthostatic hypotension, especially when combined with antihypertensives.
  • Assess psychiatric status: may exacerbate hallucinations or confusion.
  • Avoid abrupt discontinuation: sudden stop can worsen Parkinsonism.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO‑B inhibitors: may precipitate hypertensive crisis.
  • Anticholinergic agents: can mask Parkinsonian symptoms and increase side‑effects.
  • Antihypertensive drugs: additive effect on blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • SSRIs/SNRIs: potential for serotonin syndrome when combined.
  • Iron supplements: reduce levodopa absorption; separate dosing by at least two hours.
  • High‑protein meals: may decrease levodopa bioavailability, requiring timing adjustments.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage the motor symptoms of Parkinson's disease and to reduce motor fluctuations, such as "off" periods, in patients whose disease is not adequately controlled by levodopa alone.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown outside the brain and extending its therapeutic effect.

The specific dose and dosing schedule are individualized. A qualified prescriber determines the appropriate amount based on the patient’s clinical condition, response to therapy, and any comorbidities.

Safety data are limited. The medication should only be used during pregnancy or lactation if the potential benefits outweigh the possible risks to the fetus or infant, and this decision must be made by the prescribing clinician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Adding entacapone to levodopa/carbidopa reduces peripheral metabolism of levodopa, leading to more stable plasma levels, fewer "off" periods, and potentially lower total levodopa doses compared with the standard combination without entacapone.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with food to reduce gastrointestinal irritation. Tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious adverse events include dyskinesia, severe hypotension, neuroleptic malignant syndrome, and rare psychiatric disturbances such as hallucinations or psychosis. Patients should be monitored closely for these reactions, especially during dose adjustments.

The drug is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients, and in those taking non‑selective MAO‑B inhibitors. Caution is also advised for individuals with severe cardiovascular disease, narrow‑angle glaucoma, or a history of malignant melanoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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