Product image of Levodopa/Carbidopa Retard Teva (Carbidopa, Levodopa) supplied by GNH India

Levodopa/Carbidopa Retard Teva

Active Ingredient:
Carbidopa, Levodopa
Origin:
EU

Levodopa/Carbidopa Retard Teva (Carbidopa, Levodopa)

Levodopa, the active ingredient in Levodopa/Carbidopa Retard Teva, is an antiparkinson agent presented as an oral tablet for oral use. Combined with carbidopa, it treats Parkinson's disease and Parkinsonian syndromes in adults by increasing dopamine availability in the brain, helping to improve motor function and reduce rigidity.

GNH India supplies Levodopa/Carbidopa Retard Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU marketing authorisation standards and undergoes rigorous quality control to ensure consistency and safety.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Levodopa/Carbidopa is indicated for disorders of the dopaminergic system, primarily Parkinson’s disease and related Parkinsonian syndromes.

  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity, and tremor.
  • Parkinsonian syndrome: alleviates motor deficits in secondary Parkinsonism.
  • Levodopa‑responsive Parkinsonism: restores dopamine levels to reduce off‑periods and improve daily functioning.

How It Works

  • Levodopa is a precursor of dopamine that crosses the blood‑brain barrier and is decarboxylated to dopamine in central neurons. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing peripheral conversion of levodopa and thereby increasing the amount of levodopa that reaches the brain. The resulting rise in central dopamine compensates for the loss of dopaminergic neurons characteristic of Parkinson’s disease and improves neurotransmission.

Side Effects

Levodopa/Carbidopa may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional emesis.
  • Orthostatic hypotension: dizziness upon standing.
  • Dyskinesia: involuntary movements.
  • Insomnia: difficulty sleeping.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and rigidity.
  • Severe psychiatric disturbances: hallucinations or psychosis.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Severe hypotension: marked blood pressure drop.
  • Allergic reactions: rash, pruritus, or anaphylaxis.

Precautions & Warnings

When prescribing Levodopa/Carbidopa, clinicians should observe several precautionary measures to minimise risk.

  • Dose titration: start low and increase gradually to balance efficacy and side effects.
  • Monitor renal function: adjust in patients with impaired renal clearance.
  • Assess cardiovascular status: watch for orthostatic hypotension and arrhythmias.
  • Evaluate psychiatric history: risk of hallucinations or psychosis may be higher.
  • Review concomitant medications: avoid drugs that interfere with dopamine metabolism.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: can cause hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may block dopamine effects, reducing efficacy.
  • High‑dose pyridoxine (vitamin B6): accelerates peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may enhance orthostatic hypotension.
  • Iron or calcium supplements: reduce levodopa absorption if taken concurrently.
  • SSRIs and SNRIs: may increase risk of serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa Retard Teva is prescribed to manage the motor symptoms of Parkinson's disease and related Parkinsonian syndromes. By increasing dopamine levels in the brain, it helps reduce stiffness, tremor, and slowness of movement, improving overall daily function for patients with these neurodegenerative conditions.

Levodopa serves as a biochemical precursor that crosses the blood‑brain barrier and is converted into dopamine within central nervous system neurons. This conversion compensates for the dopamine deficiency that characterises Parkinson's disease, thereby restoring neurotransmission and alleviating motor deficits.

The specific dose and dosing schedule for Levodopa/Carbidopa Retard Teva are determined by the prescribing clinician based on the individual patient's disease severity, response to therapy, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Levodopa/Carbidopa in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case individually and discuss alternative options when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa/Carbidopa is considered the most effective oral therapy for symptomatic control of Parkinson’s disease because it directly replenishes central dopamine. Other classes, such as dopamine agonists or MAO‑B inhibitors, may be used as adjuncts or alternatives, but they generally provide less robust motor improvement compared with the levodopa‑carbidopa combination.

Levodopa/Carbidopa Retard Teva tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

The medication is taken orally, usually with a glass of water. It is often recommended to ingest the tablets on an empty stomach or with a light snack to optimise absorption, unless the prescriber advises otherwise. Patients should follow the timing and frequency prescribed by their healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe psychiatric disturbances such as hallucinations or psychosis, and cardiovascular complications like arrhythmias or marked hypotension. Patients should be monitored closely for any sudden changes in mental status, severe muscle rigidity, fever, or unexplained drops in blood pressure.

Patients with known hypersensitivity to levodopa, carbidopa, or any excipients in the formulation should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors, and caution is advised for those with significant cardiovascular disease, uncontrolled hypertension, or a history of severe psychiatric illness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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