Product image of Levodopa/Carbidopa Teva (Carbidopa, Levodopa) supplied by GNH India

Levodopa/Carbidopa Teva

Active Ingredient:
Carbidopa, Levodopa
Origin:
EU

Levodopa/Carbidopa Teva (Carbidopa, Levodopa)

Levodopa and Carbidopa, the active ingredients in Levodopa/Carbidopa Teva, are Antiparkinson agents presented as oral tablets for oral use. They are prescribed to manage motor symptoms in patients with Parkinson's disease and related Parkinsonian syndromes.

GNH India supplies Levodopa/Carbidopa Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

1
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Indications & Clinical Uses

Levodopa/Carbidopa is used in the management of Parkinsonian disorders, improving dopaminergic neurotransmission.

  • Parkinson's disease: alleviates bradykinesia, rigidity and tremor.
  • Parkinsonian syndrome: restores motor function in secondary Parkinsonism.
  • Rest tremor: reduces amplitude of tremor episodes.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, replenishing depleted central dopamine stores. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing peripheral conversion of levodopa, thereby increasing the amount of levodopa that reaches the brain and reducing peripheral side effects such as nausea.

Side Effects

Levodopa/Carbidopa may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating sleep.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Psychiatric disturbances: hallucinations, confusion, or depression.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Allergic reactions: rash, pruritus, or angioedema.

Precautions & Warnings

When prescribing Levodopa/Carbidopa, clinicians should consider several precautionary measures.

  • Dyskinesia monitoring: watch for involuntary movements.
  • Cardiovascular assessment: check for orthostatic hypotension.
  • Abrupt discontinuation: avoid sudden stop to prevent withdrawal effects.
  • Hepatic impairment: use with caution in liver disease.
  • Pregnancy safety: unknown, weigh risks and benefits before use.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa interacts with several medicines; some combinations should be avoided while others require careful monitoring.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic effect.
  • Pyridoxine (vitamin B6) high doses: reduces levodopa conversion.
  • High‑protein meals: interfere with levodopa absorption.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive hypotensive effect.
  • SSRIs and other serotonergic drugs: monitor for serotonin syndrome.
  • Other dopaminergic agents: may increase dyskinesia risk.
  • Iron or calcium supplements: may decrease levodopa bioavailability.

Frequently Asked Questions

Levodopa/Carbidopa is indicated for the treatment of Parkinson's disease and Parkinsonian syndrome. It helps improve motor symptoms such as bradykinesia, rigidity, and tremor by restoring dopaminergic activity in the brain.

Levodopa is a precursor of dopamine that crosses the blood‑brain barrier. Once inside the central nervous system it is converted to dopamine, replenishing the neurotransmitter that is deficient in Parkinsonian disorders. Carbidopa blocks peripheral conversion, allowing more levodopa to reach the brain.

The appropriate dose of Levodopa/Carbidopa is individualized by the prescribing clinician based on disease severity, patient response, and tolerability. Dosage regimens can vary widely, and adjustments are made during follow‑up visits.

Safety data for Levodopa/Carbidopa in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so clinicians must weigh potential benefits against possible risks before prescribing to pregnant or nursing women.

To request Levodopa/Carbidopa, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa/Carbidopa is considered the most effective symptomatic therapy for Parkinson's disease, directly replacing dopamine. Other classes such as dopamine agonists, MAO‑B inhibitors, or COMT inhibitors are often used as adjuncts or alternatives when levodopa is insufficient or causes intolerable side effects.

Levodopa/Carbidopa tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, although high‑protein meals may affect absorption. Patients are advised to follow the prescriber’s instructions regarding timing and frequency.

Serious adverse events include dyskinesia (involuntary movements), neuropsychiatric effects such as hallucinations or severe depression, and marked orthostatic hypotension. Prompt medical evaluation is required if any of these symptoms develop.

Levodopa/Carbidopa is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, or any excipients. Caution is advised for individuals with narrow‑angle glaucoma, severe cardiovascular disease, or hepatic impairment, and it should be avoided in those taking non‑selective MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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