Product image of Levodopa/Carbidopa Teva (Carbidopa, Levodopa) supplied by GNH India

Levodopa/Carbidopa Teva

Active Ingredient:
Carbidopa, Levodopa
Origin:
EU

Levodopa/Carbidopa Teva (Carbidopa, Levodopa)

Levodopa, Carbidopa, the active ingredients in Levodopa/Carbidopa Teva, are a dopamine precursor and a dopa decarboxylase inhibitor presented as an oral dosage form for oral use. They are employed to treat Parkinson's disease by restoring dopaminergic activity in patients.
GNH India supplies Levodopa/Carbidopa Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Levodopa/Carbidopa acts on the dopaminergic pathway to manage Parkinsonian disorders.

  • Parkinson's disease (early stage): improves motor function and reduces tremor.
  • Parkinson's disease (advanced stage): lessens off‑periods and enhances daily activity.
  • Parkinsonian syndrome secondary to medication: alleviates rigidity and bradykinesia.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine by aromatic L‑amino acid decarboxylase, replenishing central dopamine stores. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing peripheral conversion of levodopa, thereby increasing its availability to the brain and reducing peripheral side effects.

Side Effects

Levodopa/Carbidopa may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Orthostatic hypotension
  • Dizziness or light‑headedness
  • Dyskinesia (involuntary movements)
  • Dry mouth
  • Insomnia

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Severe depression or suicidal thoughts
  • Cardiac arrhythmias
  • Hallucinations or psychosis
  • Severe orthostatic hypotension leading to falls

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: adjust dose and monitor renal function.
  • Hepatic disease: use with caution, assess liver enzymes.
  • Cardiovascular disorders: monitor blood pressure and heart rate.
  • Psychiatric history: watch for mood changes or hallucinations.
  • Concomitant MAO‑B inhibitors: avoid due to risk of hypertensive crisis.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may diminish therapeutic effect.
  • High‑dose pyridoxine (vitamin B6): increases peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • Iron or calcium supplements: reduce levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensives: may exacerbate orthostatic hypotension.
  • SSRIs or SNRIs: monitor for serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa Teva is prescribed to manage the motor symptoms of Parkinson's disease. It works by replenishing dopamine levels in the brain, helping to reduce tremor, rigidity, and bradykinesia, thereby improving patients' daily functioning.

Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine by aromatic L‑amino acid decarboxylase. This increase in central dopamine compensates for the deficiency seen in Parkinson's disease, restoring more normal movement control.

The exact dose of Levodopa/Carbidopa Teva is determined by the prescribing clinician based on the patient’s disease stage, response, and tolerance. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions precisely.

Safety data for Levodopa/Carbidopa in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levodopa/Carbidopa is considered the most effective symptomatic therapy for Parkinson’s disease because it directly restores dopamine. Other classes, such as dopamine agonists or MAO‑B inhibitors, may be used as adjuncts or early‑stage options but generally provide less robust motor improvement.

Store Levodopa/Carbidopa Teva at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Levodopa/Carbidopa Teva is taken orally, usually with a glass of water. It may be taken with or without food, but high‑protein meals can interfere with absorption, so spacing the dose from protein‑rich meals is often recommended.

Serious risks include severe orthostatic hypotension, neuroleptic malignant syndrome, and psychiatric complications such as hallucinations or severe depression. Patients should be monitored closely for these events, especially during dose adjustments.

Individuals with known hypersensitivity to levodopa, carbidopa, or any excipients should avoid the product. It is also contraindicated in patients taking non‑selective MAO inhibitors due to the risk of hypertensive crisis, and caution is advised in those with severe cardiovascular or hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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