Product image of Levodopa/Carbidopa Teva (Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa Teva

Active Ingredient:
Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa Teva (Levodopa, Carbidopa Monohydrate)

Levodopa, the active ingredient in Levodopa/Carbidopa Teva, is a Antiparkinson agent presented as a tablet for oral use. It treats Parkinson's disease and Parkinsonian syndrome in adults.\nGNH India supplies Levodopa/Carbidopa Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Levodopa/Carbidopa Teva is used in the management of Parkinsonian disorders and related motor dysfunction.\n\n- Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity and tremor.\n- Parkinsonian syndrome: alleviates motor deficits caused by drug‑induced or secondary Parkinsonism.\n- Motor complications of Parkinsonism: reduces severity of motor fluctuations and off‑periods.

How It Works

  • Levodopa is a precursor that crosses the blood‑brain barrier and is decarboxylated to dopamine within central nervous tissue, restoring deficient dopaminergic transmission. Carbidopa, an aromatic L‑amino acid decarboxylase inhibitor, blocks peripheral conversion of levodopa, thereby increasing the amount reaching the brain and minimizing peripheral side effects such as nausea.

Side Effects

  • Levodopa/Carbidopa Teva may cause a range of adverse reactions.\n\nCommon Side Effects:\n- Nausea\n- Vomiting\n- Orthostatic hypotension\n- Dizziness\n- Headache\n- Insomnia\n\nSerious or Rare Side Effects:\n- Dyskinesia (involuntary movements)\n- Hallucinations or psychosis\n- Severe hypotension leading to syncope\n- Cardiac arrhythmias\n- Neuroleptic malignant syndrome (rare but life‑threatening).

Precautions & Warnings

  • Levodopa/Carbidopa Teva requires careful monitoring and patient education.\n\n- Blood pressure monitoring: watch for orthostatic drops, especially during dose titration.\n- Renal/hepatic impairment: adjust dose cautiously in patients with reduced organ function.\n- Cardiovascular disease: use with caution in patients with coronary artery disease or arrhythmias.\n- Psychiatric disorders: monitor for emergence of hallucinations or mood changes.\n- Abrupt discontinuation: taper gradually to avoid withdrawal symptoms.\n- Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

  • Levodopa/Carbidopa Teva can interact with several drug classes, requiring vigilance.\n\nMajor Interactions (Avoid):\n- Non‑selective MAO inhibitors (e.g., phenelzine) – risk of hypertensive crisis.\n- Antipsychotics that block dopamine receptors – may diminish therapeutic effect.\n- Sympathomimetic agents (e.g., ephedrine) – may cause severe hypertension.\n\nModerate Interactions (Monitor Closely):\n- Antihypertensive agents – additive blood‑pressure lowering effect.\n- SSRIs or SNRIs – potential for serotonin syndrome when combined with MAO‑B inhibitors.\n- Iron or vitamin B6 supplements – may reduce levodopa absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Levodopa/Carbidopa Teva is indicated for the treatment of Parkinson's disease and Parkinsonian syndrome. It helps improve motor function by reducing symptoms such as bradykinesia, rigidity, and tremor, thereby enhancing daily activities for patients with these neurodegenerative conditions.

Levodopa serves as a precursor to dopamine and crosses the blood‑brain barrier where it is converted into dopamine, replenishing the depleted neurotransmitter in Parkinsonian patients. Carbidopa blocks peripheral decarboxylation of levodopa, increasing the amount that reaches the brain and reducing peripheral side effects like nausea.

The dosage of Levodopa/Carbidopa Teva is individualized and determined by the prescribing clinician based on the patient’s disease severity, response, and tolerability. The prescriber will adjust the dose and frequency to achieve optimal symptom control while minimizing adverse effects.

Safety data for Levodopa/Carbidopa in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss the risks and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levodopa/Carbidopa is considered the most effective symptomatic therapy for Parkinson’s disease, directly restoring dopamine levels. Compared with dopamine agonists, it often provides stronger motor improvement but may cause more motor complications over time. MAO‑B inhibitors and COMT inhibitors are used as adjuncts to extend levodopa’s effect, while anticholinergics target specific tremor symptoms.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Levodopa/Carbidopa Teva is taken orally, usually as a tablet. It can be taken with or without food, although a high‑protein meal may interfere with absorption. The prescribing physician will advise the appropriate dosing schedule, which often involves multiple daily doses to maintain steady symptom control.

Serious risks include the development of dyskinesias (involuntary movements), hallucinations or psychosis, severe orthostatic hypotension that can lead to fainting, and rare but life‑threatening conditions such as neuroleptic malignant syndrome. Patients should be monitored regularly for these adverse events, especially when doses are escalated.

Levodopa/Carbidopa Teva is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, or any excipients. It should be avoided in individuals taking non‑selective MAO inhibitors, those with narrow‑angle glaucoma, or patients with severe cardiovascular disease where rapid blood‑pressure changes could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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