Product image of Levodopa/Carbidopa Teva (Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa Teva

Active Ingredient:
Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa Teva (Levodopa, Carbidopa Monohydrate)

Levodopa, the active ingredient in Levodopa/Carbidopa Teva, is a Levodopa/Carbidopa combination presented as an oral tablet for oral use. It is used to treat Parkinson's disease and related Parkinsonian syndromes by restoring dopamine levels in the brain.
GNH India supplies Levodopa/Carbidopa Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Levodopa/Carbidopa acts on the dopaminergic pathway to improve motor function in Parkinsonian disorders.

  • Parkinson's disease: reduces rigidity, bradykinesia and tremor, improving daily activities.
  • Parkinsonian syndrome: alleviates motor symptoms caused by various etiologies.
  • Rest tremor: diminishes tremor amplitude and frequency, enhancing patient comfort.

How It Works

  • Levodopa is a precursor that crosses the blood‑brain barrier and is converted to dopamine, compensating for the loss of dopaminergic neurons. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa outside the brain, thereby increasing central availability and reducing peripheral side effects such as nausea.

Side Effects

Levodopa/Carbidopa may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea or vomiting
  • Orthostatic hypotension
  • Dyskinesia (involuntary movements)
  • Dry mouth
  • Drowsiness or fatigue
  • Loss of appetite

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome-like reaction
  • Severe psychiatric disturbances (hallucinations, confusion)
  • Cardiac arrhythmias
  • Severe hypotension with syncope
  • Allergic skin reactions (rash, urticaria)

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for complications.

  • Renal impairment: adjust monitoring as drug is excreted renally.
  • Hepatic disease: use with caution due to altered metabolism.
  • Cardiovascular risk: monitor blood pressure and heart rate for orthostatic changes.
  • Psychiatric history: watch for hallucinations or mood swings.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may block dopaminergic effects.
  • High‑dose pyridoxine (vitamin B6): accelerates peripheral conversion, reducing central levodopa.

Moderate Interactions (Monitor Closely)

  • Iron or calcium supplements: may reduce levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensives: additive blood‑pressure lowering effect.
  • SSRIs or SNRIs: potential for serotonin syndrome when combined with MAO‑B inhibitors.

Frequently Asked Questions

Levodopa/Carbidopa Teva is prescribed to manage motor symptoms of Parkinson's disease and Parkinsonian syndromes. By restoring dopamine levels in the brain, it helps reduce rigidity, tremor, and bradykinesia, thereby improving patients' daily functioning and quality of life.

Levodopa serves as a precursor to dopamine. After oral administration, it crosses the blood‑brain barrier and is enzymatically converted into dopamine, compensating for the depleted neurotransmitter in Parkinsonian patients. Carbidopa blocks peripheral conversion, ensuring more levodopa reaches the brain and minimizing gastrointestinal side effects.

The exact dosage of Levodopa/Carbidopa Teva is determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Levodopa/Carbidopa in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefits justify the potential risks to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levodopa/Carbidopa is considered the most effective symptomatic therapy for Parkinson’s disease because it directly replenishes dopamine. Compared with dopamine agonists, it often provides greater motor improvement but may be associated with earlier development of dyskinesia. The combination reduces peripheral side effects relative to levodopa alone.

Levodopa/Carbidopa Teva tablets should be stored at room temperature, below 25 °C, in their original packaging. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with a glass of water. It can be taken with or without food, but consistent timing with meals may help reduce gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe psychiatric reactions such as hallucinations or confusion, neuroleptic malignant syndrome‑like events, and significant cardiovascular effects like arrhythmias or profound hypotension. Any sudden change in mental status or severe cardiovascular symptoms should prompt immediate medical evaluation.

Patients with known hypersensitivity to levodopa, carbidopa, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors due to the risk of hypertensive crisis, and caution is advised in those with uncontrolled cardiac disease or severe psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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