Product image of Levodopa Carbidopa Teva (Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa Carbidopa Teva

Active Ingredient:
Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa Carbidopa Teva (Levodopa, Carbidopa Monohydrate)

Levodopa, the active ingredient in Levodopa Carbidopa Teva, is a Antiparkinson agent presented as a tablet for oral use. It treats Parkinson's disease and Parkinsonian syndrome in adults by restoring dopamine levels in the brain.

GNH India supplies Levodopa Carbidopa Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Levodopa/Carbidopa is used in the management of Parkinsonian disorders, acting on dopaminergic pathways to improve motor function.

  • Parkinson's disease: reduces bradykinesia, rigidity and tremor, improving overall motor performance.
  • Parkinsonian syndrome: alleviates gait disturbances and muscle stiffness associated with secondary Parkinsonism.
  • Levodopa‑responsive dystonia: lessens abnormal muscle contractions and postural abnormalities.

How It Works

  • Levodopa is a precursor that crosses the blood‑brain barrier and is converted to dopamine by aromatic L‑amino acid decarboxylase. Carbidopa, a peripheral dopa‑decarboxylase inhibitor, does not cross the barrier and blocks peripheral conversion, increasing central levodopa availability while reducing peripheral side effects. The combined effect restores dopaminergic neurotransmission in the basal ganglia, improving motor control.

Side Effects

Levodopa/Carbidopa may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Headache
  • Insomnia

Serious or Rare Side Effects

  • Dyskinesia (involuntary movements)
  • Hallucinations or psychosis
  • Severe hypotension or syncope
  • Cardiac arrhythmias
  • Neuroleptic malignant‑like syndrome

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic drops, especially after the first dose.
  • Assess for dyskinesia: adjust dosage if excessive involuntary movements develop.
  • Review psychiatric history: be alert for hallucinations or mood changes.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent withdrawal.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa can interact with various medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may block therapeutic effect.
  • High‑protein meals: can reduce levodopa absorption.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Iron or calcium supplements: may decrease levodopa bioavailability.

Frequently Asked Questions

Levodopa Carbidopa Teva is indicated for the treatment of Parkinson's disease and Parkinsonian syndrome. It helps improve motor symptoms such as tremor, rigidity, and bradykinesia by restoring dopamine levels in the brain.

Levodopa is converted to dopamine once it reaches the brain, compensating for the dopamine deficiency in Parkinsonian disorders. Carbidopa inhibits the peripheral enzyme that would otherwise convert levodopa outside the brain, increasing the amount that reaches the central nervous system and reducing peripheral side effects.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s disease severity, response to therapy, and individual tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for use in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa/Carbidopa is considered the most effective symptomatic therapy for Parkinson’s disease because it directly replenishes dopamine. Other classes, such as dopamine agonists or MAO‑B inhibitors, may be used as adjuncts or in early disease, but they generally provide less robust motor improvement than levodopa combined with carbidopa.

Store the product at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain stability and potency.

Levodopa Carbidopa Teva is taken orally, usually with a glass of water. It may be taken with or without food, but high‑protein meals can interfere with absorption, so spacing the dose from protein‑rich meals is often recommended.

Serious risks include the development of dyskinesias (involuntary movements), psychiatric disturbances such as hallucinations or psychosis, severe orthostatic hypotension, and rare cardiac arrhythmias. Patients should be monitored regularly for these events.

Patients with known hypersensitivity to levodopa, carbidopa, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors. Caution is advised in patients with a history of cardiac disease, severe liver impairment, or uncontrolled psychiatric illness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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