Product image of Levodopa Plus Benserazid Al (Benserazide, Levodopa) supplied by GNH India

Levodopa Plus Benserazid Al

Active Ingredient:
Benserazide, Levodopa
Origin:
EU

Levodopa Plus Benserazid Al (Benserazide, Levodopa)

Levodopa, the active ingredient in Levodopa Plus Benserazid Al, is a Levodopa/benserazide combination presented as an oral tablet for oral use. Classified as an antiparkinson agent and marketed in the EU, it is used to improve motor function in adult patients with Parkinson's disease.

GNH India supplies Levodopa Plus Benserazid Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance for global distribution, including procurement teams in emerging markets and research institutions.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Levodopa/benserazide acts on the dopaminergic pathway to manage Parkinsonian disorders.

  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity and tremor.
  • Early-stage Parkinsonian syndrome: delays the onset of motor fluctuations.
  • Advanced Parkinson's disease with motor fluctuations: reduces "off" periods and enhances daily functioning.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, replenishing central dopaminergic stores. Benserazide, a peripheral dopa‑decarboxylase inhibitor, prevents conversion of levodopa outside the brain, increasing its central availability and minimizing peripheral side effects.

Side Effects

Levodopa/benserazide may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Headache: transient and usually resolves.
  • Insomnia: difficulty initiating sleep.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: may lead to fainting.
  • Cardiac arrhythmias: irregular heart rhythms.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Anaphylaxis: acute allergic response requiring emergency care.

Precautions & Warnings

Levodopa/benserazide requires careful monitoring to ensure safe use.

  • Monitor blood pressure: watch for orthostatic drops, especially at treatment initiation.
  • Assess psychiatric status: be alert for hallucinations or confusion.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Avoid abrupt discontinuation: taper gradually to prevent withdrawal symptoms.
  • Use with caution in elderly patients: increased sensitivity to side effects.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/benserazide can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic effect.
  • High‑protein meals: can reduce levodopa absorption.
  • MAO‑B inhibitors: increase risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive blood‑pressure lowering.
  • SSRIs and SNRIs: potential for serotonin excess.
  • Other antiparkinson drugs: may require dose adjustments.
  • Alcohol: can exacerbate dizziness and hypotension.

Frequently Asked Questions

Levodopa Plus Benserazid Al is used to treat Parkinson's disease. It helps improve motor symptoms such as tremor, rigidity, and bradykinesia by restoring dopamine levels in the brain, thereby enhancing daily functional abilities in affected patients.

Levodopa is a precursor of dopamine that crosses the blood‑brain barrier and is converted into dopamine within the central nervous system. This increase in dopamine compensates for the loss of dopaminergic neurons characteristic of Parkinson's disease, improving motor control.

The appropriate dose of Levodopa Plus Benserazid Al is determined individually by a qualified prescriber based on the patient’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control.

Safety data for Levodopa Plus Benserazid Al in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levodopa combined with benserazide is considered the most effective symptomatic therapy for Parkinson’s disease, offering superior motor improvement compared with dopamine agonists or MAO‑B inhibitors. However, it may be associated with motor complications over long‑term use, which other drug classes aim to minimize.

Levodopa Plus Benserazid Al should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with a glass of water. It may be administered with or without food, but high‑protein meals can affect absorption, so patients are often advised to coordinate dosing with meals as directed by their prescriber.

Serious risks include the development of dyskinesias (involuntary movements), severe hypotension, hallucinations, and rare but life‑threatening conditions such as neuroleptic malignant syndrome or anaphylaxis. Patients should be monitored regularly for these adverse events.

Patients with known hypersensitivity to levodopa, benserazide, or any excipients should avoid this medication. It is also contraindicated in individuals taking non‑selective MAO inhibitors and those with narrow‑angle glaucoma, unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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