Product image of Levodrop (Levodropropizine) supplied by GNH India

Levodrop

Active Ingredient:
Levodropropizine
Origin:
EU

Levodrop (Levodropropizine)

Levodropropizine, the active ingredient in Levodrop, is a antitussive presented as an oral formulation for oral use. It treats cough by reducing the sensitivity of the cough reflex in both adults and children.
GNH India supplies Levodrop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

  • Levodropropizine is an antitussive that acts on the peripheral cough reflex.
  • Acute cough: provides symptomatic relief of sudden‑onset coughing episodes.
  • Chronic cough: helps manage persistent cough associated with airway irritation.
  • Cough due to upper respiratory tract infection: reduces cough reflex sensitivity and improves comfort.

How It Works

  • Levodropropizine acts peripherally on sensory nerve endings in the respiratory mucosa. By inhibiting the activation of cough‑triggering receptors, it lowers the sensitivity of the cough reflex without crossing the blood‑brain barrier, thereby providing cough suppression without central nervous system effects.

Side Effects

Levodropropizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Abdominal discomfort: occasional cramps or pain.
  • Diarrhea: loose stools in some patients.
  • Headache: transient mild headache.
  • Dizziness: brief sensation of light‑headedness.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Allergic reactions: rash, urticaria, or angioedema.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated liver enzymes.
  • Hematologic effects: neutropenia or other blood count changes.
  • Anaphylaxis: rapid onset of systemic allergic response.
  • Respiratory depression: extremely rare, usually with concomitant CNS depressants.

Precautions & Warnings

  • When prescribing Levodropropizine, clinicians should consider several safety aspects.
  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion; weigh maternal benefit against possible infant exposure.
  • Renal impairment: dose may need adjustment in severe dysfunction.
  • Elderly: monitor for increased sensitivity to side effects such as dizziness.
  • Drug interactions: review concomitant medications for potential additive effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodropropizine may interact with other medicines; careful assessment is advised.

Major Interactions (Avoid)

  • Other antitussives: risk of excessive cough suppression.
  • QT‑prolonging agents: potential additive effect on cardiac repolarisation.
  • Strong CYP450 inhibitors: may increase plasma concentrations of levodropropizine.

Moderate Interactions (Monitor Closely)

  • Antihistamines: possible enhancement of sedative effects.
  • Bronchodilators: monitor therapeutic response, though no direct interaction.
  • Alcohol: may increase dizziness or gastrointestinal discomfort.

Frequently Asked Questions

Levodrop contains levodropropizine, an antitussive indicated for the symptomatic relief of cough associated with acute or chronic respiratory conditions. It is prescribed to reduce the frequency and intensity of coughing episodes, improving patient comfort and sleep quality.

Levodropropizine acts on peripheral sensory nerve endings in the respiratory tract. By inhibiting the activation of cough‑triggering receptors, it lowers the sensitivity of the cough reflex without affecting the central nervous system, providing cough suppression with minimal sedation.

The dosage of Levodrop is determined by the prescribing clinician based on the patient’s age, weight, severity of cough, and renal function. Typical adult regimens range from 30 mg to 60 mg taken two to three times daily, but exact dosing must follow the prescriber’s order.

Safety data for levodropropizine in pregnancy and lactation are limited. It should only be used when the expected benefit outweighs potential risks to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Levodrop, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levodrop (levodropropizine) is a peripheral antitussive, whereas agents such as codeine act centrally on the brainstem. Levodrop typically causes fewer central side effects like drowsiness or dependence, but its efficacy is limited to reducing cough reflex sensitivity rather than providing strong analgesic effects.

Levodrop should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain stability and potency throughout its shelf life.

Levodrop is taken orally. The tablet or liquid should be swallowed whole with a glass of water, preferably after meals to reduce gastrointestinal irritation. Patients should follow the prescriber’s instructions regarding frequency and duration of therapy.

Serious adverse reactions, although rare, include severe allergic responses such as rash, urticaria, angioedema, and anaphylaxis. Hepatic dysfunction and hematologic abnormalities like neutropenia have also been reported. Immediate medical attention is required if any of these symptoms develop.

Levodrop is contraindicated in individuals with known hypersensitivity to levodropropizine or any excipients in the formulation. Caution is advised for patients with severe renal impairment, uncontrolled cardiac arrhythmias, or those taking multiple central nervous system depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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