Product image of Levofloxacin Actavis (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Actavis

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Actavis (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Actavis, is a fluoroquinolone antibiotic presented as an ophthalmic preparation for ocular (subconjunctival) use. It treats bacterial eye infections such as conjunctivitis, keratitis, and corneal ulcers in patients requiring topical therapy.

GNH India supplies Levofloxacin Actavis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Levofloxacin Actavis is a fluoroquinolone antibiotic used to manage bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and promotes resolution of infection.
  • Keratitis: eradicates causative bacteria and supports corneal healing.
  • Corneal ulcer: eliminates infection and aids in ulcer closure.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, it prevents bacterial DNA supercoiling and separation, leading to inhibition of bacterial cell division and ultimately bacterial death. The action is bactericidal and is effective against a broad spectrum of Gram‑negative and Gram‑positive ocular pathogens.

Side Effects

Levofloxacin Actavis may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Temporary blurred vision.
  • Mild headache.
  • Tearing or increased lacrimation.
  • Local allergic conjunctivitis.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema).
  • Tendon rupture or tendinitis.
  • Central nervous system effects (seizures, dizziness).
  • Phototoxic skin reactions.
  • Development of resistant bacterial strains.
  • Corneal ulcer worsening despite therapy.

Precautions & Warnings

Levofloxacin Actavis should be used with attention to patient safety and proper handling.

  • Allergy assessment: avoid use in patients with known fluoroquinolone hypersensitivity.
  • Contact lens wearers: discontinue lenses during treatment to reduce irritation.
  • Systemic absorption: monitor patients with renal impairment for potential accumulation.
  • Pregnancy and lactation: prescribe only if benefits outweigh potential risks.
  • Storage: Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levofloxacin Actavis may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Systemic quinolones with antacids or multivitamins containing aluminum, magnesium, calcium, or iron (reduce absorption).
  • Concurrent use with warfarin (may increase INR and bleeding risk).
  • Co‑administration with corticosteroids (higher risk of tendon rupture).

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) (potential for CNS stimulation).
  • Diabetic agents (may affect blood glucose control).
  • Other ophthalmic antibiotics (possible antagonism or reduced efficacy).

Frequently Asked Questions

Levofloxacin Actavis is prescribed for bacterial eye infections, specifically bacterial conjunctivitis, keratitis, and corneal ulcers. It is applied directly to the eye to target the causative bacteria and help resolve the infection.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes needed for DNA replication and transcription. By inhibiting these enzymes, the drug prevents bacterial cells from multiplying, leading to bacterial death and clearance of the infection.

The dosing regimen for Levofloxacin Actavis is determined by the prescribing clinician based on the severity of the infection, patient age, and ocular condition. The prescriber will specify the number of drops, frequency, and duration of therapy.

Safety data for ocular levofloxacin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To request Levofloxacin Actavis, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum activity against many Gram‑negative and Gram‑positive ocular pathogens. Compared with older agents such as chloramphenicol or erythromycin, levofloxacin often provides faster bacterial eradication and a lower risk of resistance, though individual choice depends on susceptibility patterns and patient factors.

Levofloxacin Actavis should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from direct sunlight, excessive heat, and moisture to maintain its stability and potency.

Levofloxacin Actavis is administered as an ocular drop or subconjunctival injection, as directed by the prescriber. The recommended technique involves cleaning the eye area, instilling the prescribed number of drops, and allowing the medication to spread without blinking excessively.

Serious risks include severe allergic reactions (anaphylaxis), tendon rupture, and rare central nervous system effects such as seizures. Patients should be instructed to stop the medication and seek immediate medical attention if they experience signs of a serious reaction.

Levofloxacin Actavis should not be used by individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is also advised for patients with a history of tendon disorders or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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