Product image of Levofloxacin Beximco (Levofloxacin) supplied by GNH India

Levofloxacin Beximco

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Beximco (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Beximco, is a fluoroquinolone presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children as prescribed.

GNH India supplies Levofloxacin Beximco as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

N R Pharma Limited

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum antibacterial that targets common bacterial pathogens in several organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria, leading to clinical recovery.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating the infecting organisms.
  • Acute bacterial exacerbation of chronic bronchitis: improves lung function and shortens symptom duration.
  • Uncomplicated urinary tract infection: clears urinary pathogens and resolves dysuria.
  • Skin and soft‑tissue infections: achieves bacterial clearance and promotes wound healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of bacterial DNA, ultimately halting bacterial cell division and leading to bacterial death. This bactericidal action is effective against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Peripheral neuropathy: tingling or numbness in extremities.

Precautions & Warnings

Levofloxacin requires careful assessment before prescribing.

  • Renal impairment: dose adjustment may be needed based on kidney function.
  • History of tendon disorders: avoid use in patients with recent tendon injury.
  • QT prolongation risk: monitor ECG in patients with cardiac risk factors.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Drug interactions: review all concomitant medications for possible interactions.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Theophylline: can raise serum theophylline concentrations, leading to toxicity.
  • Cyclosporine: increased risk of nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may enhance central nervous system side effects such as seizures.
  • Diabetes medications: levofloxacin may affect glucose control, requiring monitoring.

Frequently Asked Questions

Levofloxacin Beximco is indicated for several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, uncomplicated urinary tract infections, and skin or soft‑tissue infections. The drug targets the causative bacteria, helping to resolve symptoms and prevent complications when used as directed by a healthcare professional.

Levofloxacin works by inhibiting two essential bacterial enzymes: DNA gyrase and topoisomerase IV. These enzymes are required for DNA replication and transcription. By binding to them, levofloxacin prevents bacterial DNA from unwinding and replicating, which stops bacterial cell division and leads to bacterial death, providing a bactericidal effect against a broad range of pathogens.

The dosage of Levofloxacin Beximco is determined by the prescribing clinician based on the specific infection, patient age, renal function, and other clinical factors. Healthcare providers select the appropriate strength, frequency, and duration to achieve optimal therapeutic outcomes while minimizing the risk of adverse effects.

Levofloxacin is classified as pregnancy category unknown, and its safety has not been fully established for pregnant or nursing women. It should only be used if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After validation, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Levofloxacin is a third‑generation fluoroquinolone with a broad spectrum of activity against both Gram‑positive and Gram‑negative bacteria. Compared with older agents like ciprofloxacin, levofloxacin often offers improved dosing convenience (once‑daily regimens) and enhanced activity against respiratory pathogens. However, safety considerations such as tendon toxicity and QT prolongation are shared across the class.

Levofloxacin Beximco should be stored at temperatures below 25 °C (77 °F). Keep the product in its original packaging to protect it from moisture and direct sunlight. Do not store in areas with high humidity or extreme heat, as these conditions could affect tablet integrity.

Levofloxacin Beximco is administered orally, typically as a tablet taken with or without food. Patients should swallow the tablet whole with a full glass of water and follow the prescribing clinician’s instructions regarding timing and any necessary dose adjustments.

Serious risks include tendon rupture (especially in the Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, and peripheral neuropathy. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash, or neurological symptoms.

Levofloxacin Beximco should be avoided in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with significant QT prolongation, and patients receiving concurrent medications that may cause serious drug interactions unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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