Product image of Levofloxacin Hec Pharm (Levofloxacin) supplied by GNH India

Levofloxacin Hec Pharm

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Hec Pharm (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Hec Pharm, is a fluoroquinolone presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children as prescribed.

GNH India supplies Levofloxacin Hec Pharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hec Pharm Gmbh

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum antibacterial that targets common bacterial pathogens in several organ systems.

  • Community‑acquired pneumonia: eradicates causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating the infecting organisms.
  • Acute exacerbation of chronic bronchitis: shortens symptom duration and prevents complications.
  • Uncomplicated urinary tract infection: clears uropathogens and relieves urinary symptoms.
  • Skin and soft‑tissue infections: treats Gram‑negative and Gram‑positive skin infections effectively.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By blocking these targets, it prevents bacterial DNA synthesis and transcription, leading to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a wide range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: especially in weight‑bearing tendons.
  • QT interval prolongation: may predispose to arrhythmias.
  • Severe allergic reaction: anaphylaxis or angioedema requiring urgent care.

Precautions & Warnings

Levofloxacin should be used with caution in specific clinical situations.

  • Renal function: assess and adjust dose in severe impairment.
  • History of tendon disorders: avoid use due to rupture risk.
  • Cardiac risk: monitor QT interval in patients with known prolongation.
  • Concomitant NSAIDs: increased risk of tendon injury.
  • Pregnancy and lactation: prescribe only when benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Theophylline: may raise serum theophylline concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of central nervous system side effects.
  • Corticosteroids: may heighten tendon rupture risk.

Frequently Asked Questions

Levofloxacin Hec Pharm is an oral fluoroquinolone antibiotic indicated for the treatment of community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated urinary tract infections, and skin or soft‑tissue infections caused by susceptible bacteria.

Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This blockade prevents bacterial cells from multiplying, leading to rapid bactericidal activity against a broad spectrum of Gram‑negative and Gram‑positive organisms.

The specific dose of levofloxacin is determined by the prescribing clinician based on the infection being treated, patient age, renal function, and other clinical factors. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for levofloxacin during pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levofloxacin offers once‑daily dosing and a broad spectrum that includes many respiratory, urinary, and skin pathogens, often allowing shorter courses compared with older fluoroquinolones. Compared with macrolides or beta‑lactams, it provides higher potency against certain Gram‑negative organisms but shares class‑related safety considerations such as tendon and QT risks.

Store the product at ambient temperature, preferably below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in a refrigerator or freezer.

Levofloxacin Hec Pharm is taken orally, usually as a whole tablet swallowed with a full glass of water. It may be taken with or without food, but if antacids containing aluminum or magnesium are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious adverse events include tendon rupture (especially in the Achilles tendon), QT interval prolongation that can lead to arrhythmias, and severe hypersensitivity reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, or signs of a severe allergic reaction.

Levofloxacin is contraindicated in individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use, those with established prolonged QT interval, and in children unless specifically prescribed for an approved indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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