Product image of Levofloxacin Hexal (Levofloxacin) supplied by GNH India

Levofloxacin Hexal

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Hexal (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Hexal, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections in adults and children as prescribed by a healthcare professional.

GNH India supplies Levofloxacin Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum fluoroquinolone used to treat bacterial infections in various organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory symptoms.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Uncomplicated urinary tract infection: eliminates uropathogens and resolves urinary symptoms.
  • Skin and soft‑tissue infections: controls bacterial growth in cellulitis and wound infections.
  • Chronic bronchitis exacerbation: shortens the duration of bacterial flare‑ups.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Clostridioides difficile infection: severe colitis after antibiotic use.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Photosensitivity: heightened skin reaction to sunlight.

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors before use.

  • Assess renal function: dose adjustment may be needed in renal impairment.
  • Avoid use in pregnancy: contraindicated due to potential fetal harm.
  • Monitor for tendon pain: discontinue if signs of tendonitis or rupture appear.
  • Check cardiac status: avoid in patients with known QT prolongation or arrhythmias.
  • Limit concurrent NSAID use: increased risk of central nervous system effects.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Ciprofloxacin or other fluoroquinolones: additive QT‑prolongation risk.
  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may enhance central nervous system adverse effects.
  • Theophylline: levofloxacin can raise serum theophylline levels.
  • Corticosteroids: combined use raises the chance of tendon rupture.

Frequently Asked Questions

Levofloxacin Hexal is indicated for a variety of bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, uncomplicated urinary tract infections, skin and soft‑tissue infections, and exacerbations of chronic bronchitis. The specific infection treated is determined by the prescribing clinician based on culture results and clinical presentation.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that control DNA supercoiling and replication. By inhibiting these targets, the drug prevents bacterial DNA synthesis and transcription, leading to bacterial cell death. This mechanism provides a bactericidal effect against a broad range of susceptible organisms.

The dosage of Levofloxacin Hexal is individualized by the prescriber according to the type and severity of infection, patient age, renal function, and other clinical factors. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy for each patient.

Levofloxacin Hexal is contraindicated in pregnancy because fluoroquinolones can cause fetal cartilage damage. It is also not recommended while breastfeeding, as the drug can be excreted in breast milk and may affect the infant. Alternative agents should be considered for pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levofloxacin is a third‑generation fluoroquinolone with a broad spectrum of activity and once‑daily dosing for many infections, which can improve adherence compared with some older agents that require multiple daily doses. Its safety profile is similar to other fluoroquinolones, but clinicians still monitor for class‑related risks such as tendon injury and QT prolongation.

Levofloxacin Hexal tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, direct sunlight, and excessive heat to maintain potency and stability throughout its shelf life.

Levofloxacin Hexal is taken orally, usually with a full glass of water. It can be taken with or without food, but antacids containing magnesium or aluminum should be spaced at least two hours apart to avoid reduced absorption. The exact administration schedule is set by the prescribing clinician.

Serious risks include tendon rupture (especially the Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, peripheral neuropathy, and photosensitivity. Patients should be instructed to seek immediate medical attention if they experience any of these symptoms.

Levofloxacin Hexal should not be used by individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, pregnant women, nursing mothers, patients with a history of tendon disorders related to fluoroquinolone use, and those with significant QT prolongation or uncontrolled cardiac arrhythmias. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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