Product image of Levofloxacin Kabi (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Kabi

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Kabi (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Kabi, is a fluoroquinolone antibiotic presented as an injectable solution for intravenous use. It treats a range of bacterial infections such as community‑acquired pneumonia, hospital‑acquired pneumonia, complicated urinary tract infections, acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and skin and soft‑tissue infections in adult patients.

GNH India supplies Levofloxacin Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Bulgaria Eood

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibacterial indicated for several serious bacterial infections.

  • Community‑acquired pneumonia: effective treatment of infection caused by susceptible bacteria.
  • Hospital‑acquired pneumonia: eradicates pathogens responsible for nosocomial lung infection.
  • Complicated urinary tract infection: clears bacterial colonisation in the urinary system.
  • Acute bacterial sinusitis: resolves sinus inflammation due to susceptible organisms.
  • Acute bacterial exacerbation of chronic bronchitis: reduces bacterial load during flare‑ups.
  • Skin and soft‑tissue infections: eliminates causative bacteria in dermal and subdermal tissues.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Headache
  • Dizziness
  • Rash
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation and cardiac arrhythmias
  • Clostridioides difficile‑associated colitis
  • Severe hypersensitivity reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Hepatic toxicity
  • Central nervous system effects such as seizures

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors before use.

  • Renal impairment: dose adjustment may be necessary based on creatinine clearance.
  • History of tendon disorders: avoid use in patients with prior tendon injury.
  • QT prolongation risk: monitor ECG in patients with cardiac arrhythmias.
  • Concomitant use with NSAIDs: increased risk of central nervous system side effects.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Theophylline: elevated plasma concentrations, potential toxicity.
  • Antacids containing magnesium or aluminum: reduced levofloxacin absorption.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of central nervous system adverse effects.
  • Corticosteroids: heightened risk of tendon rupture.

Frequently Asked Questions

Levofloxacin Kabi is indicated for serious bacterial infections such as community‑acquired pneumonia, hospital‑acquired pneumonia, complicated urinary tract infections, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and skin and soft‑tissue infections caused by susceptible organisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition prevents bacterial cells from reproducing and leads to rapid bacterial death.

The prescribed dose of Levofloxacin Kabi is determined by the treating physician based on the type and severity of infection, patient weight, renal function, and other clinical factors. Dosage regimens are not standardized in public information.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and only under direct medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Levofloxacin offers a broad spectrum of activity similar to other fluoroquinolones but has the advantage of once‑daily dosing for many indications due to its pharmacokinetic profile. It is often preferred for its high oral bioavailability and strong activity against respiratory pathogens.

Levofloxacin Kabi should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Levofloxacin Kabi is given as an intravenous infusion. The infusion rate and duration are set by the prescribing clinician, typically over 30‑60 minutes, and the solution should be administered using aseptic technique.

Serious risks include tendon rupture or tendinitis, QT interval prolongation leading to arrhythmias, severe hypersensitivity reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and central nervous system effects like seizures.

Levofloxacin Kabi is contraindicated in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals with significant QT prolongation without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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