Product image of Levofloxacin Kabi (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Kabi

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Kabi (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Kabi, is a fluoroquinolone antibiotic presented as an injectable solution for intravenous use. It treats a range of serious bacterial infections such as community‑acquired and hospital‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and septicemia in adult patients.

GNH India supplies Levofloxacin Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Levofloxacin is a broad‑spectrum fluoroquinolone used to treat bacterial infections in the respiratory, urinary and skin systems.
  • Community‑acquired pneumonia: achieves bacterial eradication leading to clinical cure.
  • Hospital‑acquired pneumonia: provides effective coverage against resistant pathogens.
  • Complicated urinary tract infections: clears infection and prevents recurrence.
  • Skin and soft‑tissue infections: reduces bacterial load and promotes healing.
  • Septicemia: rapidly eliminates bloodstream pathogens.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial DNA supercoiling and separation, leading to halted cell division and bacterial cell death.

Side Effects

Levofloxacin may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • Rash or mild skin irritation
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • QT‑interval prolongation and cardiac arrhythmias
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Seizures, especially in patients with CNS disorders
  • Hepatic failure or severe liver injury

Precautions & Warnings

  • Levofloxacin requires careful use in specific patient groups.
  • Renal impairment: adjust dose or monitor renal function.
  • CNS disorders: monitor for seizures or neuropsychiatric effects.
  • QT prolongation: avoid in patients with known prolonged QT or concurrent QT‑prolonging drugs.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacin can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Theophylline: can raise theophylline plasma levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of central nervous system adverse effects.
  • Corticosteroids: elevate risk of tendon rupture.
  • Cyclosporine: may increase levofloxacin concentrations, requiring monitoring.

Frequently Asked Questions

Levofloxacin Kabi is an intravenous fluoroquinolone antibiotic indicated for the treatment of serious bacterial infections such as community‑acquired and hospital‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and septicemia.

Levofloxacin works by inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial cell division and leads to bacterial cell death.

The dosage and duration of Levofloxacin Kabi are determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and local guidelines. No fixed regimen is provided here.

Levofloxacin is classified as a pregnancy category with limited data. It should only be used during pregnancy or lactation when the potential benefits justify the potential risks, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Levofloxacin offers broad‑spectrum activity against Gram‑negative and Gram‑positive bacteria and has a convenient once‑daily dosing schedule when given intravenously. Compared with older fluoroquinolones, it often provides improved potency against respiratory pathogens and a lower risk of certain resistance mechanisms.

Levofloxacin Kabi should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use to maintain stability.

Levofloxacin Kabi is administered by intravenous infusion. The infusion rate and dilution volume are determined by the healthcare professional according to the patient’s clinical condition and institutional protocols.

Serious risks include tendon rupture or tendinitis, QT‑interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and central nervous system effects like seizures, especially in patients with pre‑existing CNS disorders.

Patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, individuals with prolonged QT interval not corrected, and patients taking medications that strongly interact (e.g., certain antacids, warfarin, theophylline) should avoid using Levofloxacin Kabi unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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