Product image of Levofloxacin Krka (Levofloxacin) supplied by GNH India

Levofloxacin Krka

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Krka (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Krka, is a Fluoroquinolone presented as a tablet for oral use. It treats a range of bacterial infections in adults, including respiratory, urinary and skin infections, by targeting bacterial DNA replication.

GNH India supplies Levofloxacin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across EU markets. The product meets European pharmacopoeia standards and is available for bulk and unit‑dose distribution.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic indicated for several bacterial infections affecting the respiratory, urinary and integumentary systems.

  • Community‑acquired pneumonia: eradicates susceptible pathogens to improve respiratory function and reduce fever.
  • Acute bacterial sinusitis: clears sinus infection and relieves congestion and facial pain.
  • Acute exacerbation of chronic bronchitis: reduces bacterial load, aiding recovery of lung function.
  • Uncomplicated urinary tract infections: eliminates causative bacteria, restoring normal urinary symptoms.
  • Complicated urinary tract infections: provides broad‑spectrum coverage for resistant organisms.
  • Skin and soft tissue infections: treats cellulitis and wound infections caused by susceptible strains.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding and resealing of DNA strands, halting bacterial DNA synthesis and transcription, which leads to bacterial cell death. This bactericidal action is effective against a wide range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools that may be watery.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or swelling, especially in the Achilles.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reaction: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Precautions & Warnings

Before prescribing Levofloxacin, clinicians should consider several precautionary measures to minimize risk.

  • Assess renal function: adjust dosage in patients with reduced clearance.
  • Evaluate cardiac history: avoid in patients with known QT prolongation.
  • Avoid concurrent corticosteroid therapy: increased tendon rupture risk.
  • Monitor for tendon pain: discontinue if symptoms appear.
  • Check for hypersensitivity: discontinue if severe allergic reaction occurs.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, requiring attention to avoid clinically significant effects.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may enhance anticoagulant effect and increase bleeding risk.
  • Drugs that prolong QT interval: additive risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase central nervous system side effects.
  • Theophylline: levofloxacin can raise plasma theophylline concentrations, requiring monitoring.

Frequently Asked Questions

Levofloxacin Krka is indicated for a variety of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, as well as skin and soft‑tissue infections caused by susceptible organisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial DNA from unwinding and re‑joining, leading to bacterial cell death and eradication of the infection.

The exact dose of Levofloxacin Krka is set by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. No fixed dosing regimen is provided here.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers once‑daily dosing and a broad spectrum of activity against Gram‑negative and Gram‑positive bacteria, similar to other fluoroquinolones such as moxifloxacin. Compared with beta‑lactams, it provides better tissue penetration but carries class‑specific risks like tendon injury and QT prolongation.

Levofloxacin Krka tablets should be stored at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not store in a refrigerator or freezer.

Levofloxacin Krka is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid taking it simultaneously with antacids or supplements containing calcium, magnesium or iron, as these may reduce absorption.

The most serious adverse events include tendon rupture (especially Achilles), QT interval prolongation leading to arrhythmias, severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome, and Clostridioides difficile‑associated colitis. Prompt medical attention is required if any of these occur.

Levofloxacin should be avoided in patients with a known hypersensitivity to fluoroquinolones, a history of tendon disorders related to quinolone use, uncontrolled arrhythmias, or those taking other QT‑prolonging drugs without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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