Product image of Levofloxacin Krka (Levofloxacin) supplied by GNH India

Levofloxacin Krka

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Krka (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Krka, is a fluoroquinolone presented as an oral tablet for oral use. It treats a range of bacterial infections in adults and children as prescribed.

GNH India supplies Levofloxacin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum antibacterial indicated for several common bacterial infections.

  • Community‑acquired pneumonia: eradicates the causative pathogens and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute bacterial exacerbation of chronic bronchitis: shortens symptom duration and prevents complications.
  • Urinary tract infections: eliminates uropathogens and resolves urinary symptoms.
  • Skin and soft‑tissue infections: treats cellulitis and related bacterial skin conditions.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, it prevents the unwinding and resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limited.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional vertigo or light‑headedness.
  • Rash: mild skin erythema.
  • Photosensitivity: increased sensitivity to sunlight.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • QT prolongation: cardiac rhythm disturbance requiring monitoring.
  • Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome.
  • Central nervous system effects: seizures or psychosis in susceptible individuals.

Precautions & Warnings

Levofloxacin should be used with caution and under professional supervision.

  • Renal impairment: dose adjustment may be required.
  • History of tendon disorders: avoid use if prior tendon injury.
  • Cardiac arrhythmias: monitor QT interval in patients with known prolongation.
  • Pregnancy and lactation: safety not established; weigh risks and benefits.
  • Concomitant medications: review for potential interactions before prescribing.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacin can interact with several drug classes, affecting efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • NSAIDs (e.g., ibuprofen): heightened risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase serum theophylline levels.
  • Cyclosporine: potential for increased nephrotoxicity.
  • Corticosteroids: combined use may raise tendon‑rupture risk.

Frequently Asked Questions

Levofloxacin Krka is prescribed for a variety of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, urinary tract infections, and skin or soft‑tissue infections. The specific indication depends on the clinician’s assessment of the infection type and severity.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication. Inhibiting these enzymes prevents bacterial DNA synthesis, leading to cell death. This mechanism gives levofloxacin a broad‑spectrum, bactericidal activity against many Gram‑positive and Gram‑negative organisms.

The dosage of Levofloxacin Krka is determined by the prescribing healthcare professional based on the infection being treated, patient age, renal function, and other clinical factors. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate individual circumstances before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin is a third‑generation fluoroquinolone offering once‑daily dosing and a broad spectrum of activity. Compared with older fluoroquinolones, it has improved activity against Gram‑positive organisms and a more favorable pharmacokinetic profile, but it shares class‑related safety considerations such as tendon‑rupture risk.

Levofloxacin Krka tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Levofloxacin Krka is taken orally, usually with a full glass of water. It can be taken with or without food, but antacids containing aluminum or magnesium should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture (especially the Achilles tendon), QT‑interval prolongation leading to cardiac arrhythmias, severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome, and central nervous system effects like seizures in susceptible patients.

Levofloxacin Krka should be avoided in patients with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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