Levofloxacin Macleods Pharma Uk (Levofloxacin Hemihydrate)

Levofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This blockade prevents bacterial DNA from unwinding, halting cell division and leading to bacterial death.

The prescribed dose of levofloxacin is determined by the treating clinician based on the type and severity of infection, patient age, weight, renal function, and local resistance patterns. Only a qualified prescriber should set the dosing regimen.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product does not have a defined pregnancy category. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacin offers once‑daily dosing for many infections and has a broad spectrum covering both Gram‑negative and Gram‑positive organisms. Compared with ciprofloxacin, it often provides higher tissue penetration and may be preferred for respiratory infections, though both share similar safety considerations such as tendon and QT‑interval risks.

Levofloxacin tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Levofloxacin is taken orally, usually as a tablet swallowed whole with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals or other medications.

Serious adverse events include tendon rupture or tendinitis, QT‑interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatic injury, and peripheral neuropathy. Patients should seek immediate medical attention if they experience any of these symptoms.

Levofloxacin is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, a history of tendon disorders related to fluoroquinolone use, prolonged QT interval, or in children and adolescents unless specifically indicated. Caution is also advised for pregnant or breastfeeding women when no safer alternative exists.