Product image of Levofloxacin Macure (Levofloxacin) supplied by GNH India

Levofloxacin Macure

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Macure (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Macure, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a range of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, uncomplicated urinary tract infections, and skin and soft‑tissue infections in adult patients.

GNH India supplies Levofloxacin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary and skin systems.

  • Community‑acquired pneumonia: eradicates the typical pathogens and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute bacterial exacerbation of chronic bronchitis: shortens the duration of worsening symptoms.
  • Uncomplicated urinary tract infection: eliminates uropathogens and resolves urinary symptoms.
  • Skin and soft‑tissue infections: treats cellulitis and other bacterial skin conditions.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death. This bactericidal action is effective against a broad spectrum of Gram‑positive and Gram‑negative organisms, making it a potent fluoroquinolone antibiotic.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or loss of function.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Levofloxacin, clinicians should consider several safety factors.

  • Renal impairment: dose adjustment may be required in reduced kidney function.
  • Central nervous system effects: monitor for seizures or confusion, especially in the elderly.
  • QT prolongation risk: avoid in patients with known cardiac conduction disorders.
  • Photosensitivity: advise patients to limit sun exposure and use protective clothing.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Antacids, iron, or sucralfate: reduce levofloxacin absorption; separate dosing by at least 2 hours.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Theophylline or cyclosporine: plasma levels can rise, leading to toxicity.
  • Other QT‑prolonging agents: additive risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: heightened risk of tendon rupture.
  • Diabetic agents: possible hypoglycemia; monitor blood glucose.
  • Antihistamines: may increase central nervous system stimulation.

Frequently Asked Questions

Levofloxacin Macure is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated urinary tract infections, and skin and soft‑tissue infections. It targets the causative bacteria to clear the infection and improve clinical symptoms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these enzymes, the drug prevents bacterial DNA from unwinding and replicating, leading to bacterial cell death and resolution of the infection.

The dosage of Levofloxacin Macure is determined by the prescribing healthcare professional based on the specific infection, patient age, renal function, and other clinical factors. Patients should follow the exact regimen provided by their prescriber.

The safety of levofloxacin in pregnancy and lactation has not been definitively established. It is classified as pregnancy category unknown, and clinicians should weigh potential benefits against risks. Breastfeeding mothers should consult their physician before use.

To request Levofloxacin Macure, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin is a third‑generation fluoroquinolone with a broad spectrum of activity and once‑daily dosing for many indications, offering convenience compared with some older agents that require multiple daily doses. Its pharmacokinetic profile provides high tissue penetration, but safety considerations such as tendon risk are shared across the class.

Levofloxacin Macure should be stored at ambient temperature, below 25 °C, in the original container to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiration date.

Levofloxacin Macure is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid concurrent intake of antacids, iron, or sucralfate unless spaced at least two hours apart to ensure proper absorption.

Serious risks include tendon rupture, especially in older adults or those on corticosteroids; QT interval prolongation leading to cardiac arrhythmias; severe allergic reactions such as anaphylaxis; and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, or severe skin reactions.

Levofloxacin should be avoided in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, patients with a history of tendon disorders related to fluoroquinolone use, and those with significant QT prolongation or uncontrolled cardiac arrhythmias. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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