Product image of Levofloxacin Macure (Levofloxacin) supplied by GNH India

Levofloxacin Macure

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Macure (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Macure, is a fluoroquinolone presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH India supplies Levofloxacin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum fluoroquinolone antibiotic used to treat bacterial infections in several organ systems.

  • Community‑acquired respiratory tract infections: effective treatment of bacterial pneumonia and bronchitis.
  • Urinary tract infections: eradicates common uropathogens causing cystitis and pyelonephritis.
  • Skin and soft tissue infections: combats Staphylococcus and Streptococcus species in cellulitis and wound infections.
  • Acute bacterial sinusitis: resolves sinus inflammation caused by susceptible bacteria.
  • Acute bacterial pharyngitis: clears streptococcal throat infections.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, often linked to sudden activity.
  • QT interval prolongation: may predispose to cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Clostridioides difficile infection: colitis due to disruption of gut flora.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors before use.

  • Renal function assessment: dose adjustment may be needed in impaired kidneys.
  • Hypersensitivity: avoid in patients with known allergy to fluoroquinolones.
  • Elderly patients: increased risk of tendon injury; advise caution with physical activity.
  • Cardiac risk: monitor patients with existing QT prolongation or arrhythmias.
  • Concomitant QT‑prolonging drugs: avoid or monitor closely for additive effects.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and INR.
  • Cyclosporine: elevated levofloxacin levels, risk of toxicity.
  • Theophylline: increased risk of seizures and cardiac effects.
  • Other QT‑prolonging agents: additive risk of arrhythmias.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened central nervous system side effects.
  • Insulin or oral hypoglycemics: potential for hypoglycemia.
  • Corticosteroids: increased tendon rupture risk.
  • Diabetic agents: possible blood‑glucose fluctuations.
  • Oral contraceptives: reduced effectiveness, consider alternative contraception.

Frequently Asked Questions

Levofloxacin Macure is prescribed for a variety of bacterial infections, including community‑acquired respiratory tract infections such as pneumonia and bronchitis, urinary tract infections, skin and soft tissue infections, acute bacterial sinusitis, and acute bacterial pharyngitis. The specific indication depends on the pathogen susceptibility and clinical judgment of the prescriber.

Levofloxacin works by inhibiting two essential bacterial enzymes: DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are required for DNA replication and transcription. By blocking their activity, levofloxacin prevents bacterial DNA from being properly unwound and resealed, leading to bacterial cell death.

The dosage of Levofloxacin Macure is determined by the prescribing clinician based on the type and severity of infection, patient age, renal function, and other clinical factors. Only a qualified health professional can set the appropriate dose and treatment duration.

The safety of levofloxacin in pregnancy and lactation has not been definitively established. It is generally avoided unless the potential benefit outweighs the potential risk to the fetus or infant. Pregnant or nursing patients should discuss alternatives with their healthcare provider.

To order Levofloxacin Macure, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum activity against many Gram‑negative and Gram‑positive bacteria. Compared with beta‑lactams, it provides once‑daily dosing and good tissue penetration, but it carries specific risks such as tendon injury and QT prolongation. Choice of therapy depends on pathogen susceptibility, patient risk factors, and local resistance patterns.

Levofloxacin Macure should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, and store it away from direct sunlight or heat sources to maintain stability.

Levofloxacin Macure is administered orally, typically as a tablet or oral suspension, and should be taken with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any dietary considerations.

Serious risks of levofloxacin include tendon rupture (especially in older adults), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should be educated to report any sudden joint pain, palpitations, or severe skin reactions promptly.

Levofloxacin Macure should be avoided in individuals with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with uncontrolled cardiac arrhythmias or prolonged QT interval, and in children unless specifically indicated. The prescriber must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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