Product image of Levofloxacin Noridem (Levofloxacin) supplied by GNH India

Levofloxacin Noridem

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Noridem (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Noridem, is a fluoroquinolone antibiotic presented as an intravenous solution for intravenous use. It treats a range of bacterial infections in adults and children as prescribed by a healthcare professional.

GNH India supplies Levofloxacin Noridem as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibacterial indicated for several serious infections.

  • Community‑acquired pneumonia: effective treatment of bacterial pneumonia acquired outside hospital settings.
  • Complicated urinary tract infection: eradicates pathogens causing upper urinary tract involvement.
  • Skin and soft tissue infections: resolves bacterial cellulitis and related dermal infections.
  • Intra‑abdominal infections: combats mixed‑flora infections following abdominal surgery or perforation.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding of DNA, halting bacterial replication and transcription, which leads to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema or itching.
  • Dizziness: occasional light‑headed sensation.
  • Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • QT interval prolongation: can precipitate cardiac arrhythmias.
  • Clostridioides difficile infection: severe colitis after disruption of gut flora.
  • Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Seizures: particularly in patients with CNS disorders.
  • Hepatic failure: rare but potentially life‑threatening liver injury.

Precautions & Warnings

Levofloxacin requires careful assessment of patient‑specific factors before use.

  • Renal impairment: dose adjustment may be needed based on creatinine clearance.
  • History of tendon disorders: avoid use in patients with prior tendon injury or tendon‑related surgery.
  • QT prolongation risk: monitor ECG in patients with known cardiac conduction abnormalities.
  • Pregnancy Category C: prescribe only when potential benefits justify potential fetal risk.
  • Concomitant antacids or multivitamins: separate administration by at least two hours to ensure absorption.
  • Store at below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect leading to higher bleeding risk.
  • Theophylline: elevated serum theophylline concentrations, raising toxicity potential.
  • Co‑administration with other fluoroquinolones: additive QT‑prolongation and CNS effects.

Moderate Interactions (Monitor Closely)

  • Antacids or supplements containing aluminum, magnesium, calcium, iron, or zinc: may reduce levofloxacin absorption; separate dosing by at least two hours.
  • Corticosteroids: may increase the risk of tendon rupture when used together.

Frequently Asked Questions

Levofloxacin Noridem is an intravenous fluoroquinolone antibiotic used to treat serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and intra‑abdominal infections when oral therapy is not appropriate.

Levofloxacin works by binding to bacterial DNA gyrase and topoisomerase IV, enzymes that control DNA supercoiling and replication. Inhibiting these enzymes prevents bacterial DNA synthesis, leading to rapid bactericidal activity against a broad range of Gram‑positive and Gram‑negative organisms.

The specific dose and duration of Levofloxacin Noridem are determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal function, and other clinical factors. No fixed regimen is provided here.

Levofloxacin is classified as Pregnancy Category C, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Levofloxacin is the L‑isomer of ofloxacin and generally offers higher potency and broader Gram‑positive coverage compared with ciprofloxacin, which is more active against Gram‑negative organisms. Both belong to the fluoroquinolone class, but levofloxacin often requires once‑daily dosing and may have a lower risk of certain resistance patterns.

Store the intravenous solution at temperatures below 25 °C, in its original packaging, protected from light, moisture, and extreme temperature fluctuations. Do not freeze the product. Follow aseptic techniques when preparing the infusion to maintain sterility.

Levofloxacin Noridem is administered by intravenous infusion. The solution is diluted in an appropriate compatible fluid and infused over a period recommended by the prescriber, typically ranging from 30 minutes to 1 hour, depending on the clinical situation.

Serious risks include tendon rupture (especially Achilles), QT‑interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and central nervous system effects like seizures. Patients should be monitored for any of these events.

Levofloxacin Noridem should be avoided in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with uncontrolled QT prolongation, and individuals receiving concomitant medications that significantly increase the risk of tendon injury or cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Levofloxacin

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT