Product image of Levofloxacin Olikla (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Olikla

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Olikla (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Olikla, is a fluoroquinolone presented as an ophthalmic preparation for ocular use. It is employed to treat bacterial infections of the eye, such as conjunctivitis, keratitis, and corneal ulcers, in adult patients.

GNH India supplies Levofloxacin Olikla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets while providing reliable logistics for timely delivery.

Manufacturer / TM Owner

Olikla S.R.O.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and resolves infection symptoms.
  • Keratitis: eradicates causative bacteria, promoting corneal healing.
  • Corneal ulcer: eliminates infection, supporting tissue repair and preventing progression.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the ATP‑binding sites of these enzymes, it prevents DNA strand separation, halting bacterial DNA synthesis and transcription, resulting in bactericidal activity against a broad spectrum of ocular pathogens.

Side Effects

Levofloxacin ophthalmic solution may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation: mild burning or stinging upon instillation.
  • Redness: transient conjunctival hyperemia.
  • Foreign body sensation: feeling of grit in the eye.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Corneal ulcer worsening: progression despite therapy.
  • Allergic reaction: swelling, itching, or rash around the eye.
  • Tendon rupture: rare systemic tendon injury, especially in susceptible patients.

Precautions & Warnings

When prescribing Levofloxacin ophthalmic solution, consider the following precautions.

  • Allergy assessment: confirm no known hypersensitivity to fluoroquinolones or formulation components.
  • Corneal integrity: avoid use on perforated corneas or severe epithelial defects without specialist advice.
  • Contact lens wear: discontinue lenses during treatment and resume only after therapy completion.
  • Systemic fluoroquinolone exposure: monitor patients with a history of tendon disorders or QT prolongation.
  • Pregnancy and lactation: use only if the potential benefit outweighs the risk, after professional evaluation.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct light in the original container.

Avoid Interactions

Levofloxacin can interact with other medications; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: may reduce ocular absorption if administered concurrently.
  • Systemic fluoroquinolones: additive risk of tendon toxicity and QT prolongation.
  • Cyclosporine ophthalmic: potential for increased ocular irritation.

Moderate Interactions (Monitor Closely)

  • Corticosteroid eye drops: may mask signs of infection, requiring close monitoring.
  • NSAID eye drops: possible additive irritation.
  • Warfarin: rare reports of altered coagulation; monitor INR if combined.

Frequently Asked Questions

Levofloxacin Olikla is an ophthalmic formulation of levofloxacin hemihydrate indicated for the treatment of bacterial eye infections, specifically bacterial conjunctivitis, keratitis, and corneal ulcers. It targets susceptible Gram‑negative and Gram‑positive ocular pathogens to clear infection and promote healing.

Levofloxacin exerts its antibacterial effect by inhibiting the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are essential for DNA supercoiling, replication, and transcription. Blocking their activity prevents bacterial DNA synthesis, leading to rapid bacterial cell death.

The dosing regimen for Levofloxacin Olikla is determined by the prescribing clinician based on the severity of the infection, the patient’s age, and ocular condition. Healthcare professionals set the frequency and duration of eye‑drop administration according to current clinical guidelines.

Safety data for levofloxacin ophthalmic use in pregnancy and lactation are limited. The product should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum coverage and rapid bactericidal activity. Compared with older agents such as ciprofloxacin, levofloxacin often provides higher potency against resistant strains and requires less frequent dosing. However, choice of therapy should consider local resistance patterns and patient‑specific factors.

Levofloxacin Olikla should be stored at ambient temperature, preferably below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability and efficacy.

The product is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption, avoiding immediate blinking.

Serious adverse reactions include worsening of corneal ulcers, severe allergic responses such as swelling or rash around the eye, and rare systemic events like tendon rupture or QT‑interval prolongation. Patients should seek immediate medical attention if they experience any of these symptoms.

Levofloxacin Olikla is contraindicated in individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is also advised for patients with a history of tendon disorders, significant cardiac arrhythmias, or severe ocular surface disease without specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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