Product image of Levofloxacin Stada (Levofloxacin) supplied by GNH India

Levofloxacin Stada

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacin Stada (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacin Stada, is a fluoroquinolone presented as an oral dosage form for systemic use. It is indicated for the treatment of various bacterial infections in adults, such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, and skin and soft‑tissue infections.

GNH India supplies Levofloxacin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for global distribution.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections of the respiratory, urinary and skin systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria, improving respiratory symptoms.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating infection.
  • Acute exacerbations of chronic bronchitis: controls bacterial flare‑ups, aiding airway function.
  • Uncomplicated urinary tract infections: clears uropathogens, relieving dysuria and frequency.
  • Skin and soft‑tissue infections: treats bacterial skin lesions, promoting healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the enzyme‑DNA complex, it prevents unwinding and resealing of DNA strands, halting bacterial DNA synthesis and transcription, which results in bactericidal activity against susceptible Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or rupture, especially in the Achilles.
  • QT prolongation: cardiac rhythm disturbances.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile colitis: severe diarrhea due to intestinal flora disruption.

Precautions & Warnings

Levofloxacin should be used with caution in specific patient populations and clinical situations.

  • Renal impairment: adjust dose or monitor renal function.
  • History of tendon disorders: avoid use or monitor for tendon pain.
  • Concomitant QT‑prolonging drugs: assess risk of cardiac arrhythmia.
  • Elderly patients: increased risk of CNS effects; monitor closely.
  • Pregnancy and breastfeeding: use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Iron supplements: decrease oral bioavailability.
  • Warfarin: may increase anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

  • Theophylline: possible increased serum concentrations.
  • Corticosteroids: heightened risk of tendon rupture.

Frequently Asked Questions

Levofloxacin Stada is prescribed for a range of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, as well as skin and soft‑tissue infections. It targets susceptible Gram‑negative and Gram‑positive organisms in these conditions.

Levofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This blockade prevents the unwinding and resealing of DNA strands, leading to halted bacterial growth and ultimately bacterial cell death.

The dosage of Levofloxacin Stada is determined by the prescribing healthcare professional based on the specific infection, patient characteristics, and local guidelines. Only a qualified prescriber should set the dose and duration of therapy.

Levofloxacin Stada should only be used during pregnancy or while breastfeeding if the potential benefits outweigh the possible risks to the fetus or infant. The decision must be made by a qualified healthcare provider after careful assessment.

To request Levofloxacin Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Levofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum activity against many Gram‑negative and Gram‑positive bacteria. Compared with beta‑lactam antibiotics, it often provides once‑daily oral dosing and good tissue penetration, but it carries class‑specific risks such as tendon toxicity and QT prolongation that must be weighed against its benefits.

Levofloxacin Stada should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and store it out of direct sunlight to maintain stability.

Levofloxacin Stada is administered orally, typically as a tablet or capsule taken with or without food, according to the prescriber's instructions. The exact form and dosing schedule should follow the healthcare professional’s guidance.

Serious risks include tendon rupture (especially in the Achilles tendon), QT interval prolongation that can lead to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be monitored for these events, and therapy should be discontinued if they occur.

Levofloxacin Stada should be avoided in individuals with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients taking concomitant medications that significantly prolong the QT interval, and in pregnant or breastfeeding women unless clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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