Product image of Levofloxacin Stada (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Stada

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Stada (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Stada, is a fluoroquinolone presented as an oral tablet for oral use. It is employed to treat bacterial infections of the respiratory tract, urinary system, and skin in adult patients and is commonly prescribed in community‑acquired settings.

GNH India supplies Levofloxacin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides ensuring regulatory documentation for export to EU and other markets.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

  • Levofloxacin is a fluoroquinolone antibiotic that targets bacterial DNA replication in several infection types.
  • Community‑acquired respiratory tract infections: reduces bacterial load and improves clinical symptoms in adult patients.
  • Urinary tract infections: eradicates susceptible uropathogens and resolves infection signs.
  • Skin and soft tissue infections: eliminates causative bacteria and promotes healing of infected lesions.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for supercoiling and separation of DNA during replication and transcription. By binding to the quinolone‑resistance‑determining region of these enzymes, it prevents DNA strand re‑ligation, leading to accumulation of double‑strand breaks and bacterial cell death. This bactericidal action is concentration‑dependent and effective against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Tendon rupture: risk of Achilles or other tendon tears, especially in older adults.
  • QT interval prolongation: may predispose to cardiac arrhythmias.
  • Severe allergic reaction: includes anaphylaxis, skin rash, and angioedema.

Precautions & Warnings

Levofloxacin should be used with caution in specific patient groups and clinical situations.

  • Renal impairment: dose adjustment may be required based on renal function.
  • History of tendon disorders: avoid use due to increased risk of tendon rupture.
  • Concomitant QT‑prolonging drugs: monitor cardiac rhythm.
  • Pregnancy and lactation: use only if clearly needed after risk assessment.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Store at below 25°C: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of CNS stimulation and seizures.

Moderate Interactions (Monitor Closely)

  • Theophylline: may raise plasma levels, monitor for toxicity.
  • Cyclosporine: may increase levofloxacin concentrations.
  • Diabetes medications (e.g., insulin, sulfonylureas): may cause hypoglycemia.

Frequently Asked Questions

Levofloxacin Stada is an oral fluoroquinolone antibiotic indicated for the treatment of adult patients with community‑acquired respiratory tract infections, uncomplicated urinary tract infections, and skin or soft‑tissue infections caused by susceptible bacteria.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. Inhibition leads to DNA breaks, halting bacterial growth and causing cell death, which provides a bactericidal effect against a wide range of pathogens.

The prescribed dose of Levofloxacin Stada is determined by the treating physician based on the infection type, severity, patient age, renal function and other clinical factors. Dosage regimens may differ for respiratory, urinary or skin infections.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when clearly needed after a risk‑benefit assessment by the prescriber. Breast‑feeding mothers should discuss potential exposure with their healthcare professional.

To place an enquiry, visit the product page on gnhindia.com, enter the required quantity and submit the request. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum coverage and once‑daily dosing for many infections. Compared with macrolides or beta‑lactams, it often provides faster bacterial eradication but carries class‑specific risks such as tendon injury and QT prolongation, which must be weighed by the prescriber.

Store Levofloxacin Stada at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity to maintain potency.

Levofloxacin Stada is taken orally with a full glass of water. It may be taken with or without food, but if gastrointestinal upset occurs, it can be taken with a light meal. Swallow tablets whole; do not crush or chew unless instructed by a healthcare professional.

Serious adverse events include tendon rupture or inflammation, QT‑interval prolongation leading to arrhythmias, severe hypersensitivity reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be educated to report sudden joint pain, palpitations, rash or persistent diarrhea promptly.

Levofloxacin Stada is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and patients receiving concomitant medications that significantly prolong the QT interval. Caution is also advised for pregnant or lactating women unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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