Product image of Levofloxacin Unimed Pharma (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacin Unimed Pharma

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacin Unimed Pharma (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacin Unimed Pharma, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. Formulated for topical administration, the solution delivers the active compound directly to the eye surface, providing rapid antimicrobial activity. It treats bacterial eye infections such as conjunctivitis, keratitis and corneal ulcer in adult patients.

GNH India supplies Levofloxacin Unimed Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European GMP guidelines and provides regulatory documentation for importers.

Manufacturer / TM Owner

Unimed Pharma Spol.S R.O.

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Indications & Clinical Uses

Levofloxacin is indicated for bacterial ocular infections, acting on the pathogens that cause inflammation of the eye surface and cornea.

  • Bacterial conjunctivitis: reduces bacterial load, alleviating redness, discharge and discomfort.
  • Keratitis: eradicates causative bacteria, promoting healing of the corneal epithelium.
  • Corneal ulcer: eliminates infection, supporting tissue repair and preventing perforation.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these targets, it prevents bacterial DNA supercoiling and separation, leading to halted bacterial cell division and eventual cell death. The drug’s high affinity for bacterial enzymes over human counterparts provides selective antibacterial activity when applied to the eye.

Side Effects

Ocular administration of levofloxacin may be associated with local and systemic adverse reactions.

Common Side Effects

  • Eye irritation: transient burning or stinging on instillation.
  • Redness: mild conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Corneal ulcer worsening: rare progression despite therapy.
  • Severe allergic reaction: eyelid swelling, hives, or anaphylaxis.
  • Tendon rupture: extremely rare systemic effect reported with fluoroquinolones.

Precautions & Warnings

Before prescribing levofloxacin eye drops, clinicians should consider several safety measures.

  • Allergy assessment: verify no known hypersensitivity to fluoroquinolones or ocular preservatives.
  • Contact lens use: advise removal of lenses before and after instillation to avoid drug adsorption.
  • Ocular surface disease: monitor patients with dry eye or epithelial defects closely.
  • Systemic fluoroquinolone therapy: avoid concurrent use to reduce cumulative toxicity risk.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as safety data are limited.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levofloxacin eye drops can interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon and central nervous system toxicity.
  • Topical corticosteroids: may mask signs of infection and delay healing.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may reduce tear production, enhancing ocular irritation.
  • Non‑steroidal anti‑inflammatory eye drops (NSAIDs): combined use may increase corneal toxicity.
  • Antacids or multivitamins containing aluminum/magnesium: if systemic absorption occurs, may reduce levofloxacin bioavailability.

Frequently Asked Questions

Levofloxacin Unimed Pharma is an ophthalmic fluoroquinolone antibiotic indicated for the treatment of bacterial eye infections such as bacterial conjunctivitis, keratitis and corneal ulcer. It is applied directly to the eye to eradicate the causative bacteria and promote healing of the ocular surface.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

The dosage regimen for Levofloxacin Unimed Pharma is determined by the prescribing clinician based on the severity of the infection, the patient’s age, renal function and other clinical factors. The prescriber selects the appropriate number of drops and frequency according to established guidelines.

Safety data for levofloxacin use during pregnancy and lactation are limited. The drug should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should discuss the risk‑benefit profile with the patient before prescribing.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Levofloxacin Unimed Pharma. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers broad‑spectrum activity against Gram‑negative and Gram‑positive bacteria and penetrates ocular tissues well. Compared with older agents such as ciprofloxacin, it often requires fewer daily doses and may have a lower resistance profile, making it a preferred choice for many bacterial eye infections.

Store the ophthalmic solution at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging until use. Do not freeze the product, and discard any solution that appears discolored or cloudy.

Levofloxacin is applied as eye drops. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. If using contact lenses, they should be removed before instillation and re‑inserted after the drops are absorbed.

Serious risks include severe allergic reactions such as eyelid swelling, hives or anaphylaxis, and rare progression of corneal ulcer despite therapy. Systemic fluoroquinolone‑related effects, such as tendon rupture, have been reported, though they are extremely uncommon with topical ocular use.

Patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the ophthalmic formulation should avoid this product. It is also contraindicated in individuals receiving concurrent systemic fluoroquinolone therapy due to additive toxicity risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

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