Product image of Levofloxacina Abc (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacina Abc

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacina Abc (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacina Abc, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Levofloxacina Abc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics across multiple continents.

Manufacturer / TM Owner

Abc Farmaceutici S.P.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria in various organ systems.

  • Community‑acquired pneumonia: eradicates causative bacteria, improving respiratory symptoms.
  • Acute bacterial sinusitis: reduces bacterial load, relieving congestion and facial pain.
  • Acute exacerbation of chronic bronchitis: targets infection, decreasing sputum and dyspnea.
  • Uncomplicated urinary tract infection: eliminates uropathogens, providing rapid symptom relief.
  • Complicated urinary tract infection: offers broad‑spectrum activity against resistant upper‑tract pathogens.
  • Skin and soft tissue infections: treats cellulitis and wound infections caused by susceptible bacteria.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the quinolone‑binding pocket of these enzymes, it prevents the resealing of DNA strands during transcription and replication, leading to bacterial cell death. The dual targeting of gyrase and topoisomerase IV provides potent bactericidal activity against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation leading to arrhythmia
  • Severe allergic reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

When prescribing Levofloxacina Abc, clinicians should consider several safety measures.

  • Assess renal function: adjust dosage in patients with impaired clearance.
  • Monitor for tendon pain: discontinue if signs of tendinitis or rupture appear.
  • Avoid use in patients with known hypersensitivity to fluoroquinolones.
  • Use with caution in the elderly: higher risk of central nervous system effects.
  • Review concomitant QT‑prolonging drugs: combined use may increase arrhythmia risk.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacina Abc interacts with several medicines; awareness of the most significant interactions is essential.

Major Interactions (Avoid)

  • Antacids or supplements containing magnesium, aluminum, calcium, or iron: markedly reduce levofloxacin absorption.
  • Warfarin: may increase INR and bleeding risk.
  • Theophylline: levofloxacin can raise plasma theophylline levels, risking toxicity.
  • Cyclosporine: increased cyclosporine concentrations may occur.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may enhance central nervous system stimulation.
  • Oral contraceptives: efficacy may be reduced, consider additional contraception.
  • Diabetes medications: levofloxacin may affect glucose control.

Frequently Asked Questions

Levofloxacina Abc is indicated for several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, as well as skin and soft‑tissue infections such as cellulitis.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By binding to these targets, it prevents DNA strand resealing, leading to bacterial cell death and a broad‑spectrum antibacterial effect.

The prescribed dose is set by the treating clinician based on the type and severity of infection, patient age, weight, renal function and any relevant comorbidities. No universal dosing regimen is provided here.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It is generally avoided unless the potential benefit outweighs the risk, and a healthcare professional should be consulted.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers a broader spectrum against Gram‑positive organisms and often requires once‑daily dosing, whereas ciprofloxacin is more active against certain Gram‑negative bacteria and may need multiple daily doses. Resistance patterns, safety profiles and specific infection sites guide the choice between them.

Levofloxacina Abc should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct sunlight to maintain potency.

The product is supplied as oral tablets that are swallowed whole with water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing with meals or other medications.

Serious adverse events include tendon rupture or tendinitis, especially in older adults; QT‑interval prolongation that can lead to arrhythmias; and severe hypersensitivity reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt medical attention is required if these occur.

Patients with a known hypersensitivity to levofloxacin or any fluoroquinolone should avoid the drug. Those with a history of tendon disorders, uncontrolled arrhythmias, or who are taking other QT‑prolonging agents should be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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