Product image of Levofloxacina Accord (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacina Accord

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacina Accord (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacina Accord, is a fluoroquinolone presented as an oral dosage form for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, urinary tract infections and skin and soft tissue infections in adult patients.

GNH India supplies Levofloxacina Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its global distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Levofloxacina Accord (levofloxacin) is used to treat bacterial infections in several organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria, leading to clinical improvement and resolution of pulmonary infiltrates.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating the infecting organisms, relieving congestion and facial pain.
  • Urinary tract infections: clears the urinary tract of susceptible pathogens, alleviating dysuria, frequency and systemic symptoms.
  • Skin and soft tissue infections: combats Gram‑negative and Gram‑positive bacteria, promoting healing of cellulitis, abscesses and wound infections.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the quinolone‑binding site, it prevents the resealing of DNA strands during replication, causing accumulation of double‑strand breaks and bacterial cell death. This bactericidal activity is concentration‑dependent and effective against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacina Accord may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose, sometimes watery stools.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness or imbalance.

Serious or Rare Side Effects

  • Tendon rupture or tendinitis: especially Achilles, may occur during or after therapy.
  • QT interval prolongation: can lead to cardiac arrhythmias.
  • Severe hypersensitivity reactions: including Stevens‑Johnson syndrome, toxic epidermal necrolysis, or anaphylaxis.

Precautions & Warnings

Levofloxacina Accord requires careful use in specific patient groups and conditions.

  • Renal function: adjust use in patients with impaired kidney function and monitor serum creatinine.
  • Age considerations: use cautiously in elderly patients due to increased risk of tendon injury.
  • Phototoxicity: advise patients to avoid excessive sunlight or UV exposure during treatment.
  • Drug resistance: limit use to confirmed bacterial infections to reduce development of resistance.
  • Pregnancy and lactation: avoid unless clearly needed; safety data are limited.
  • Store at below 25°C: keep in the original container, protect from moisture and heat.

Avoid Interactions

Levofloxacina Accord can interact with several medicines, requiring avoidance or close monitoring.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption; separate dosing by at least 2 hours.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of central nervous system stimulation and seizures.
  • Warfarin: may enhance anticoagulant effect, requiring close INR monitoring.
  • Theophylline: levofloxacin can increase serum theophylline levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: combined use may raise risk of tendon rupture.
  • Diabetic agents (e.g., insulin, sulfonylureas): levofloxacin may cause dysglycemia; monitor blood glucose.
  • Cyclosporine: may increase cyclosporine concentrations; monitor levels.

Frequently Asked Questions

Levofloxacina Accord contains levofloxacin, a fluoroquinolone antibiotic indicated for the treatment of several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, urinary tract infections and skin or soft‑tissue infections caused by susceptible organisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that control DNA supercoiling and replication. Inhibiting these enzymes prevents bacterial DNA from being properly replicated, leading to bacterial cell death and resolution of the infection.

The dose of Levofloxacina Accord is set by the prescribing clinician based on the specific infection, its severity, the patient’s renal function, age and other clinical factors. No fixed dosing regimen is provided here.

Safety data for levofloxacin in pregnancy and lactation are limited and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacina Accord delivers levofloxacin, a third‑generation fluoroquinolone with a broad spectrum against Gram‑negative and many Gram‑positive bacteria. Compared with older agents such as ciprofloxacin, levofloxacin often offers once‑daily dosing and enhanced activity against respiratory pathogens, though safety considerations remain similar across the class.

Store Levofloxacina Accord at temperatures below 25 °C, in the original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not use the product after the expiry date printed on the label.

Levofloxacina Accord is taken orally with a full glass of water. It may be taken with or without food, but if antacids or supplements containing calcium, magnesium or iron are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious adverse events include tendon rupture or tendinitis (especially of the Achilles tendon), QT‑interval prolongation that can lead to cardiac arrhythmias, and severe hypersensitivity reactions such as Stevens‑Johnson syndrome, toxic epidermal necrolysis or anaphylaxis. Patients should seek immediate medical attention if these occur.

Levofloxacina Accord should be avoided in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that may cause dangerous QT prolongation unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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