Levofloxacina Aurobindo Italia (Levofloxacin)

• Levofloxacin is a broad‑spectrum fluoroquinolone antibacterial used to treat several serious infections.
• Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
• Acute bacterial sinusitis: clears sinus infection and relieves congestion.
• Skin and soft‑tissue infections: eliminates pathogenic bacteria and promotes wound healing.
• Urinary tract infections: resolves infection and restores urinary health.
• Intra‑abdominal infections: targets mixed bacterial flora and supports recovery after abdominal surgery.

• Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, the drug prevents the supercoiling and separation of DNA strands, leading to bacterial cell death and a bactericidal effect against a wide range of Gram‑positive and Gram‑negative organisms.

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Diarrhea: loose stools, sometimes watery.
• Headache: transient cranial discomfort.
• Dizziness: sensation of light‑headedness.
• Rash: mild skin erythema or itching.
• Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects

• Tendon rupture: sudden pain or loss of function, especially in the Achilles tendon.
• QT interval prolongation: risk of cardiac arrhythmias.
• Clostridioides difficile infection: severe colitis with watery diarrhea.
• Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
• Hepatic failure: jaundice, elevated bilirubin, and liver dysfunction.
• Seizures: especially in patients with pre‑existing CNS disorders.

• Levofloxacin requires careful consideration of patient‑specific factors before use.
• Renal function: adjust dose in patients with impaired clearance.
• QT interval: avoid in individuals with known prolongation or concurrent QT‑prolonging drugs.
• Tendon health: discontinue if tendon pain, swelling, or inflammation occurs.
• CNS effects: monitor for seizures in patients with a history of seizures or other CNS disorders.
• Pregnancy and lactation: use only if benefits outweigh potential risks.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
• Warfarin: may increase INR and bleeding risk.
• Theophylline: increased theophylline plasma concentrations and toxicity.

Moderate Interactions (Monitor Closely)

• NSAIDs: may enhance central nervous system stimulation.
• Corticosteroids: increased risk of tendon rupture when combined.