Product image of Levofloxacina Farmoz (Levofloxacin) supplied by GNH India

Levofloxacina Farmoz

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacina Farmoz (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacina Farmoz, is a Fluoroquinolone antibiotic presented as a injection for intravenous use. It treats a range of serious bacterial infections in adults and pediatric patients when indicated.
GNH India supplies Levofloxacina Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections affecting various organ systems.

  • Community‑acquired pneumonia: achieves clinical cure and microbiological eradication.
  • Hospital‑acquired pneumonia: provides coverage for Gram‑negative and atypical pathogens.
  • Complicated urinary tract infections: resolves infection and prevents recurrence.
  • Complicated intra‑abdominal infections: aids bacterial clearance after source control.
  • Skin and soft‑tissue infections: reduces lesion size and promotes healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the enzyme‑DNA complex, it prevents strand separation, leading to halted bacterial proliferation and eventual cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacina Farmoz may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or rupture, especially Achilles.
  • QT prolongation: cardiac rhythm disturbance that may lead to arrhythmia.
  • Severe hypersensitivity: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Clostridioides difficile colitis: severe diarrhea due to intestinal flora disruption.

Precautions & Warnings

Levofloxacina Farmoz requires careful clinical monitoring to minimize risks.

  • Renal impairment: adjust therapy and monitor renal function.
  • CNS effects: monitor for seizures or confusion, especially in patients with pre‑existing CNS disorders.
  • Phototoxicity: advise patients to avoid excessive sunlight exposure.
  • Pregnancy and lactation: use only if benefits outweigh risks; safety not established.
  • Drug resistance: limit use to confirmed bacterial infections to reduce resistance development.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacina Farmoz can interact with several medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect; monitor INR closely.
  • Theophylline: increased risk of toxicity; monitor serum levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may increase risk of CNS stimulation.
  • Diabetic agents (e.g., insulin, sulfonylureas): may cause hypoglycemia; monitor glucose.
  • Corticosteroids: may increase risk of tendon rupture; advise caution.

Frequently Asked Questions

Levofloxacina Farmoz is indicated for serious bacterial infections such as community‑acquired and hospital‑acquired pneumonia, complicated urinary tract infections, complicated intra‑abdominal infections, and skin and soft‑tissue infections. It is prescribed when a broad‑spectrum fluoroquinolone is appropriate for the identified or suspected pathogen.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing these enzymes from separating DNA strands, the drug halts bacterial cell division and leads to rapid bacterial death, providing a bactericidal effect against many Gram‑positive and Gram‑negative organisms.

The dosage of Levofloxacina Farmoz is determined by the prescribing clinician based on the infection type, severity, patient age, weight, renal function, and other clinical factors. Only a qualified healthcare professional can set the appropriate dose and infusion schedule.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Levofloxacin offers a once‑daily dosing option and a broad spectrum that includes many Gram‑negative and atypical pathogens, similar to moxifloxacin but with a slightly different activity profile against some Gram‑positive organisms. Compared with beta‑lactam antibiotics, levofloxacin provides oral and IV formulations and does not require beta‑lactamase stability, but it carries class‑specific risks such as tendon toxicity.

Levofloxacina Farmoz must be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect from light, and avoid freezing or shaking the solution. Do not use the product if the temperature has been exceeded or if the solution appears discolored.

The product is given by intravenous infusion. It is typically diluted in a compatible IV fluid and administered over a period defined by the prescriber, often 30‑60 minutes for standard doses. Administration should follow aseptic technique and institutional infusion guidelines.

Serious adverse events include tendon rupture (especially Achilles), QT‑interval prolongation that can precipitate arrhythmias, severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome, and Clostridioides difficile‑associated colitis. Patients should be monitored closely for these events, and therapy should be stopped immediately if they occur.

Levofloxacina Farmoz is contraindicated in patients with a known hypersensitivity to levofloxacin or any fluoroquinolone. Caution is advised for individuals with a history of tendon disorders, uncontrolled cardiac arrhythmias, severe renal impairment, or those taking interacting medications such as certain antacids, warfarin, or theophylline. Pregnant or breastfeeding women should only use it when clearly needed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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