Product image of Levofloxacina Galenica Senese (Levofloxacin) supplied by GNH India

Levofloxacina Galenica Senese

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacina Galenica Senese (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacina Galenica Senese, is a fluoroquinolone antibiotic presented as an injection solution for intravenous use. It treats a range of serious bacterial infections in adults and pediatric patients when oral therapy is unsuitable or ineffective.

GNH India supplies Levofloxacina Galenica Senese as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other regulated markets. The product complies with EU pharmacopeial standards and is manufactured under strict quality‑assurance protocols.

Manufacturer / TM Owner

Industria Farmaceutica Galenica Senese Srl

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Indications & Clinical Uses

Levofloxacin is indicated for several serious bacterial infections across different organ systems.

  • Community‑acquired pneumonia: achieves clinical cure and microbiological eradication in adult patients.
  • Complicated urinary tract infections: resolves infection and prevents recurrence in patients with structural or functional urinary abnormalities.
  • Skin and soft tissue infections: reduces lesion size and eliminates causative pathogens.
  • Intra‑abdominal infections: provides effective bacterial clearance after surgical or percutaneous source control.
  • Bacterial prostatitis: improves symptoms and eradicates the infecting organism in men with chronic prostatitis.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the ATP‑binding sites of these enzymes, it prevents DNA strand separation and transcription, leading to rapid bacterial cell death. The dual inhibition confers broad‑spectrum activity against Gram‑negative and Gram‑positive organisms, including many resistant strains.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • QT interval prolongation leading to arrhythmia
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions such as anaphylaxis

Precautions & Warnings

Before initiating levofloxacin therapy, clinicians should consider several precautionary measures to minimize risk.

  • Renal function: adjust dosing in patients with impaired clearance.
  • Hepatic impairment: monitor liver enzymes and use with caution.
  • History of tendon disorders: avoid in patients with prior tendon injury or who are on corticosteroids.
  • Cardiac risk: assess QT interval and avoid in patients with known prolongation or electrolyte disturbances.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Co‑administration with other fluoroquinolones: increased risk of toxicity.
  • Antacids or supplements containing magnesium, aluminum, calcium, or iron: markedly reduce levofloxacin absorption.
  • Warfarin: may enhance anticoagulant effect and raise INR.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened risk of central nervous system adverse events.
  • Systemic corticosteroids: increased likelihood of tendon injury.
  • Theophylline: potential for elevated plasma concentrations and toxicity.

Frequently Asked Questions

Levofloxacina Galenica Senese contains levofloxacin, a fluoroquinolone antibiotic indicated for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, intra‑abdominal infections, and bacterial prostatitis, when intravenous therapy is required.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes needed for DNA replication and transcription. By binding to their ATP‑binding sites, it prevents DNA strand separation, halting bacterial cell division and leading to rapid bacterial death across a broad spectrum of pathogens.

The specific dose and treatment duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight, renal function, and other clinical factors. Healthcare professionals should follow local guidelines and the product label when prescribing.

Safety data for levofloxacin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician after careful assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levofloxacin offers broad‑spectrum coverage against many Gram‑negative and Gram‑positive bacteria, including some resistant strains, and can be administered intravenously for rapid serum concentrations. Compared with beta‑lactams, it may be chosen when oral therapy is not feasible or when organisms are known to be resistant to other classes.

Levofloxacina Galenica Senese should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect from light, and avoid freezing or shaking the solution to maintain stability and potency.

The product is supplied as an injectable solution for intravenous infusion. Administration is performed by a qualified healthcare professional, typically using a sterile infusion set, and the rate of infusion is set according to the prescribing information and patient-specific factors.

Serious adverse events include tendon rupture or inflammation, QT‑interval prolongation that can lead to arrhythmias, Clostridioides difficile‑associated colitis, severe allergic reactions such as anaphylaxis, and central nervous system effects like seizures. Patients should be monitored closely for these rare but potentially life‑threatening reactions.

Levofloxacina Galenica Senese is contraindicated in patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is advised for individuals with a history of tendon disorders, significant cardiac arrhythmias, or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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