Product image of Levofloxacina Generis (Levofloxacin) supplied by GNH India

Levofloxacina Generis

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacina Generis (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacina Generis, is a fluoroquinolone antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH India supplies Levofloxacina Generis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary, abdominal and skin systems.

  • Community‑acquired pneumonia: eradicates the causative pathogens and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute bacterial exacerbation of chronic bronchitis: shortens symptom duration and prevents complications.
  • Complicated urinary tract infections: eliminates resistant uropathogens and resolves infection.
  • Complicated intra‑abdominal infections: provides broad‑spectrum coverage for mixed bacterial flora.
  • Skin and soft‑tissue infections: treats cellulitis, abscesses and other bacterial skin conditions.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents DNA synthesis and transcription, leading to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Clostridioides difficile infection: severe colitis after antibiotic use.
  • Hepatic toxicity: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Before prescribing Levofloxacina Generis, clinicians should consider several safety measures.

  • Assess renal function: dose adjustment may be needed in impaired kidneys.
  • Avoid in patients with known hypersensitivity to fluoroquinolones.
  • Use with caution in the elderly: higher risk of tendon injury and CNS effects.
  • Monitor for tendon pain or swelling: discontinue if symptoms appear.
  • Avoid concomitant use with other QT‑prolonging agents.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacina Generis can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Co‑administration with systemic fluoroquinolones: additive toxicity.
  • Concurrent use with tizanidine: may cause severe hypotension.
  • Combination with other QT‑prolonging drugs (e.g., macrolides, antipsychotics): increased arrhythmia risk.
  • Use with non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened central nervous system side effects.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: elevated risk of tendon rupture.
  • Theophylline: levofloxacin may increase plasma theophylline levels.
  • Warfarin: potential enhancement of anticoagulant effect, requiring INR monitoring.

Frequently Asked Questions

Levofloxacina Generis, containing levofloxacin, is prescribed for a range of bacterial infections including community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, complicated urinary tract infections, intra‑abdominal infections, and skin or soft‑tissue infections. The exact indication depends on the clinician’s assessment of the infection type and severity.

Levofloxacin blocks two essential bacterial enzymes—DNA gyrase (topoisomerase II) and topoisomerase IV. By inhibiting these enzymes, the drug prevents DNA replication and transcription, leading to bacterial cell death. This mechanism provides broad‑spectrum bactericidal activity against many Gram‑positive and Gram‑negative organisms.

The dosage of Levofloxacina Generis is determined by the prescribing physician based on the specific infection, patient age, renal function, and other clinical factors. Only a qualified health professional can set the appropriate dose and treatment duration.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacin offers broad‑spectrum coverage and convenient once‑daily oral dosing, which can be advantageous over some beta‑lactams that require multiple daily doses. However, fluoroquinolones carry specific safety warnings, such as tendon toxicity and QT prolongation, that may make other classes preferable in certain patients.

Levofloxacina Generis should be stored at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Levofloxacina Generis is administered orally, typically as a tablet or oral suspension, depending on the formulation supplied. It should be taken with a full glass of water, and food may be taken with or without the dose unless otherwise directed by the prescriber.

Serious risks include tendon rupture (especially the Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should be instructed to seek immediate medical attention if any of these events occur.

Levofloxacina Generis should be avoided in individuals with a known hypersensitivity to levofloxacin or any fluoroquinolone, patients with a history of tendon disorders related to fluoroquinolone use, and those taking medications that significantly prolong the QT interval unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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