Product image of Levofloxacina Hikma (Levofloxacin) supplied by GNH India

Levofloxacina Hikma

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacina Hikma (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacina Hikma, is a fluoroquinolone antibiotic presented as an intravenous formulation for parenteral use. It treats a range of bacterial infections in adult patients.

GNH India supplies Levofloxacina Hikma as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

Levofloxacina Hikma is a fluoroquinolone that targets bacterial DNA replication and is indicated for several serious infections.

  • Community‑acquired pneumonia: effective against typical and atypical pathogens, improving respiratory outcomes.
  • Complicated urinary tract infections: eradicates Gram‑negative organisms causing pyelonephritis.
  • Skin and skin structure infections: treats moderate to severe bacterial cellulitis and wound infections.
  • Intra‑abdominal infections: covers mixed aerobic and anaerobic bacteria in complicated cases.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By stabilizing the enzyme‑DNA complex, it prevents DNA strand separation, halting bacterial replication and transcription, leading to bacterial cell death.

Side Effects

Levofloxacina Hikma may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Rash
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation
  • Clostridioides difficile‑associated diarrhea
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Peripheral neuropathy

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Renal function assessment: adjust dosing in patients with impaired clearance.
  • Tendon health monitoring: discontinue if tendon pain or swelling occurs.
  • Cardiac monitoring: avoid in patients with known QT prolongation.
  • Concurrent corticosteroid use: increase risk of tendon injury.
  • Hypersensitivity: discontinue at first sign of severe allergic reaction.
  • Store at below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Levofloxacina Hikma can interact with other medicines; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Tizanidine: may cause profound hypotension.
  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: increased anticoagulant effect, monitor INR.
  • Cyclosporine: elevated cyclosporine levels, risk of nephrotoxicity.
  • Other fluoroquinolones: additive toxicity, avoid co‑administration.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: heightened risk of tendon rupture.
  • Theophylline: increased plasma concentrations, monitor for toxicity.
  • NSAIDs: may enhance central nervous system stimulation.
  • Sulfonylureas: enhanced hypoglycaemic effect, monitor glucose.
  • Diabetic agents (insulin): possible increased hypoglycaemia.

Frequently Asked Questions

Levofloxacina Hikma is an intravenous fluoroquinolone antibiotic used to treat serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and intra‑abdominal infections. It is prescribed for adult patients when a broad‑spectrum, parenteral option is required.

Levofloxacin blocks bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes that control DNA supercoiling and replication. By preventing these enzymes from functioning, the drug stops bacterial DNA synthesis and transcription, leading to bacterial cell death and resolution of the infection.

The dose of Levofloxacina Hikma is set by the prescribing clinician based on the type and severity of infection, the patient’s renal function, weight, and any relevant comorbidities. No fixed regimen is provided here; the prescriber tailors therapy to each individual case.

Levofloxacina Hikma falls under an unknown pregnancy category, and safety data are limited. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levofloxacina Hikma contains levofloxacin, the L‑isomer of ofloxacin, offering higher potency and better tissue penetration than many older fluoroquinolones. It provides a broader spectrum against Gram‑negative organisms and is often preferred for severe infections requiring intravenous therapy, though safety considerations remain similar across the class.

Levofloxacina Hikma should be stored at temperatures below 25 °C, protected from light and moisture. Keep the product in its original packaging until use and avoid exposing it to extreme heat or humidity to maintain stability and potency.

Levofloxacina Hikma is administered intravenously by a healthcare professional. The infusion is typically given over a set period as directed by the prescriber, using aseptic technique and appropriate IV equipment. Administration details, including infusion rate, are determined by the treating clinician.

Serious risks include tendon rupture or tendinitis, QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should be monitored closely for these events.

Levofloxacina Hikma should be avoided in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, individuals with significant QT prolongation, and patients with uncontrolled epilepsy. Clinical judgment is required for all other contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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