Product image of Levofloxacina Pharmakern (Levofloxacin) supplied by GNH India

Levofloxacina Pharmakern

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacina Pharmakern (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacina Pharmakern, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections in adult patients, including respiratory, urinary and skin infections.
GNH India supplies Levofloxacina Pharmakern as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmakern Portugal – Produtos Farmacêuticos, Sociedade Unipessoal, Lda.

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Indications & Clinical Uses

Levofloxacina Pharmakern is a fluoroquinolone antibacterial used to treat several common bacterial infections.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: clears sinus infection and relieves congestion.
  • Acute exacerbation of chronic bronchitis: reduces bacterial load and eases breathing difficulty.
  • Uncomplicated urinary tract infection: eliminates uropathogens and resolves urinary symptoms.
  • Complicated urinary tract infection: treats resistant organisms in upper urinary tract.
  • Skin and soft‑tissue infections: combats bacterial skin infections and promotes healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By blocking these targets, the drug prevents bacterial DNA synthesis and transcription, leading to bactericidal activity against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacina Pharmakern may cause adverse reactions ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Severe allergic reactions: anaphylaxis, swelling, or hives.
  • Hepatic toxicity: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Before prescribing Levofloxacina Pharmakern, clinicians should consider several safety measures.

  • Assess renal function: dose adjustment may be required in impaired kidneys.
  • Monitor for tendon pain: discontinue if signs of tendonitis or rupture appear.
  • Avoid use in patients with known hypersensitivity to fluoroquinolones.
  • Use with caution in elderly patients: higher risk of CNS and cardiovascular effects.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Levofloxacina Pharmakern can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Systemic fluoroquinolones: additive toxicity, especially tendon and CNS effects.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Other QT‑prolonging agents: heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Theophylline: levofloxacin can increase serum theophylline levels.
  • NSAIDs: may raise risk of central nervous system stimulation.
  • Corticosteroids: concurrent use may increase tendon rupture risk.

Frequently Asked Questions

Levofloxacina Pharmakern is indicated for several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, as well as skin and soft‑tissue infections. The drug targets the causative bacteria to help resolve symptoms and prevent disease progression.

Levofloxacin, the active ingredient, blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. Inhibiting these enzymes stops bacterial cells from copying their genetic material, leading to bacterial death and clearance of the infection.

The specific dose and duration of Levofloxacina Pharmakern are determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for levofloxacin in pregnancy are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. It is also excreted in breast milk, so breastfeeding mothers should consult their physician before using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacin offers broad‑spectrum activity similar to other fluoroquinolones but has a once‑daily dosing convenience and strong activity against both Gram‑negative and Gram‑positive pathogens. Compared with older agents like ciprofloxacin, levofloxacin often provides better lung penetration, making it a preferred choice for respiratory infections.

Levofloxacina Pharmakern should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.

The medication is supplied as an oral tablet and is taken by mouth with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include tendon rupture (especially the Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash or neurological symptoms.

Levofloxacina Pharmakern is contraindicated in individuals with a known hypersensitivity to levofloxacin or any fluoroquinolone. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use, those with prolonged QT interval, and in children or adolescents unless specifically indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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