Product image of Levofloxacina Rafarm (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacina Rafarm

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacina Rafarm (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacina Rafarm, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial infections of the eye such as conjunctivitis and keratitis in patients of all ages.
GNH India supplies Levofloxacina Rafarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Levofloxacina Rafarm is a fluoroquinolone antibiotic used to manage bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and resolves infection of the conjunctiva.
  • Bacterial keratitis: eradicates corneal pathogens and promotes healing of the corneal epithelium.
  • Other susceptible ocular infections: effective against Gram‑positive and Gram‑negative organisms causing eye infections.

How It Works

  • Levofloxacin hemihydrate inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Levofloxacina Rafarm may cause ocular and systemic reactions.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Transient eye redness.
  • Blurred vision lasting a few minutes.
  • Itching or foreign‑body sensation.
  • Mild tearing.
  • Temporary eyelid swelling.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Corneal ulceration or perforation.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Vision loss.
  • Persistent intraocular inflammation.
  • Tendon rupture (systemic exposure).

Precautions & Warnings

Before using Levofloxacina Rafarm, consider the following precautions.

  • Hypersensitivity: discontinue immediately if signs of severe allergic reaction appear.
  • Indication specificity: use only for confirmed bacterial ocular infections; avoid viral or fungal eye conditions.
  • Fluoroquinolone allergy: avoid in patients with known hypersensitivity to levofloxacin or other fluoroquinolones.
  • Corneal integrity: exercise caution in eyes with epithelial defects or recent surgery.
  • Pregnancy and lactation: safety not established; prescribe only if potential benefit outweighs risk.
  • Store at below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Levofloxacina Rafarm can interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Concurrent use of systemic fluoroquinolones: may increase risk of additive toxicity.
  • Cation‑containing eye drops (e.g., aluminum‑based antacids): can reduce ocular absorption.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask signs of infection or increase risk of corneal thinning.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for delayed wound healing.
  • Antidiabetic medications: systemic absorption may affect glucose control; observe blood sugar levels.

Frequently Asked Questions

Levofloxacina Rafarm is a fluoroquinolone ophthalmic preparation indicated for the treatment of bacterial conjunctivitis, bacterial keratitis, and other susceptible ocular infections. It is applied directly to the eye to eradicate pathogenic bacteria and promote resolution of the infection.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division, leading to a bactericidal effect that clears susceptible ocular pathogens.

The dosing regimen for Levofloxacina Rafarm is determined by the prescribing clinician based on the type and severity of the ocular infection, patient age, and other clinical factors. The prescriber will specify the number of drops, frequency, and duration of therapy.

Safety data for Levofloxacina Rafarm in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Levofloxacina Rafarm belongs to the fluoroquinolone class, offering broad‑spectrum activity against Gram‑positive and Gram‑negative bacteria. Compared with other ocular fluoroquinolones such as moxifloxacin, levofloxacin provides similar potency but may differ in dosing frequency and formulation preferences.

Store the product at temperatures below 25 °C in its original packaging. Protect it from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability and potency.

Levofloxacina Rafarm is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac, avoiding contact between the dropper tip and the eye.

Serious risks include severe allergic reactions such as anaphylaxis, corneal ulceration or perforation, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and vision loss. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation should avoid using this product. It is also contraindicated in eyes with viral or fungal infections that require alternative therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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