Product image of Levofloxacine Almus (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacine Almus

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacine Almus (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacine Almus, is a fluoroquinolone presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults, including respiratory, urinary and skin infections, and related bacterial DNA processes.

GNH India supplies Levofloxacine Almus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance, and reliable logistics for global distribution. Our network ensures timely delivery and support for healthcare providers across diverse markets.

Manufacturer / TM Owner

Almus France

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Indications & Clinical Uses

  • Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary, and skin systems.
  • Community‑acquired respiratory tract infections: effective treatment of bacterial pneumonia and acute bronchitis.
  • Urinary tract infections: eradicates common uropathogens causing cystitis and pyelonephritis.
  • Skin and soft tissue infections: resolves cellulitis, abscesses, and wound infections caused by susceptible bacteria.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating causative organisms.
  • Acute bacterial prostatitis: achieves bacterial clearance in prostate infections.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By stabilizing the enzyme–DNA complex, it prevents strand separation, halting DNA synthesis and transcription, which leads to bacterial cell death. The drug penetrates tissues and fluids, achieving concentrations above the minimum inhibitory concentration for susceptible strains, which enhances its clinical efficacy.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset often transient.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: mild to moderate cranial discomfort.
  • Dizziness: transient vertigo or light‑headedness.

Serious or Rare Side Effects

  • Tendon rupture: risk of Achilles or other tendon tears, especially in older adults.
  • QT prolongation: potential cardiac arrhythmia requiring monitoring.
  • Severe allergic reactions: anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis.
  • Central nervous system effects: seizures or psychosis in susceptible patients.

Precautions & Warnings

  • Before prescribing Levofloxacine Almus, clinicians should consider several safety considerations.
  • Renal impairment: dose adjustment may be required and renal function should be monitored.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • History of tendon disorders: avoid in individuals with prior tendon inflammation or rupture.
  • Concomitant QT‑prolonging drugs: assess cardiac risk before co‑administration.
  • Pregnancy and breastfeeding: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and risk of bleeding.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened risk of central nervous system stimulation and seizures.

Moderate Interactions (Monitor Closely)

  • Theophylline: levofloxacin can raise plasma theophylline levels, requiring dose adjustment.
  • Corticosteroids: combined use may increase risk of tendon rupture.
  • Diabetic agents (e.g., insulin, sulfonylureas): may cause hypoglycemia; monitor blood glucose.

Frequently Asked Questions

Levofloxacine Almus, containing levofloxacin, is prescribed for a range of bacterial infections including community‑acquired respiratory tract infections such as pneumonia and bronchitis, urinary tract infections like cystitis and pyelonephritis, skin and soft‑tissue infections, acute bacterial sinusitis, and acute bacterial prostatitis.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication. By stabilizing the enzyme‑DNA complex, it halts DNA synthesis and transcription, leading to bacterial cell death. This mechanism provides broad‑spectrum bactericidal activity against many Gram‑negative and Gram‑positive organisms.

The exact dose of Levofloxacine Almus is set by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and any concomitant medications. Dosage adjustments may be needed for patients with impaired kidney function or other special considerations.

Levofloxacine Almus falls under an unknown pregnancy category, meaning safety has not been definitively established. It should be used during pregnancy or lactation only when the potential benefits justify the possible risks to the fetus or infant, and after careful evaluation by a healthcare professional.

To request Levofloxacine Almus, submit an enquiry on the product page at gnhindia.com with the desired quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacine Almus contains levofloxacin, a third‑generation fluoroquinolone with a broad spectrum of activity and once‑daily dosing options for many infections. Compared with older agents like ciprofloxacin, levofloxacin often offers higher potency against Gram‑positive organisms and better lung penetration, making it a preferred choice for respiratory infections.

Levofloxacine Almus should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Levofloxacine Almus is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid concurrent intake of antacids containing aluminum or magnesium, as these can reduce absorption. The exact schedule is determined by the prescribing clinician.

Serious risks include tendon rupture (especially in older adults or those on corticosteroids), QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and central nervous system effects like seizures. Patients should seek immediate medical attention if they experience sudden joint pain, palpitations, rash, or neurological symptoms.

Levofloxacine Almus is contraindicated in patients with a known hypersensitivity to levofloxacin or any fluoroquinolone. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, those taking medications that significantly prolong the QT interval, and patients with severe renal impairment unless dose‑adjusted by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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