Product image of Levofloxacine Eg (Levofloxacin) supplied by GNH India

Levofloxacine Eg

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacine Eg (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacine Eg, is a fluoroquinolone antibiotic presented as an oral formulation for oral use. It treats bacterial infections such as urinary tract, respiratory, skin and soft‑tissue infections, prostatitis and gonorrhea in adult patients.

GNH India supplies Levofloxacine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum fluoroquinolone used to treat infections caused by susceptible bacteria in several organ systems.

  • Urinary tract infections: eradicates uropathogens and relieves dysuria and frequency.
  • Respiratory tract infections: clears pathogens in bronchitis, sinusitis and community‑acquired pneumonia.
  • Skin and soft‑tissue infections: resolves cellulitis, abscesses and wound infections.
  • Prostatitis: eliminates bacterial involvement of the prostate gland.
  • Gonorrhea: treats uncomplicated Neisseria gonorrhoeae infections.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacine Eg may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, occasionally watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Rash: mild skin erythema or pruritus.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur during or after therapy.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile infection: colitis with diarrhea.
  • Peripheral neuropathy: sensory disturbances.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Levofloxacine Eg requires careful consideration of patient‑specific factors before use.

  • Renal impairment: dose adjustment may be needed based on renal function.
  • History of tendon disorders: avoid use in patients with prior tendon injury.
  • QT prolongation risk: monitor ECG in patients with cardiac disease or electrolyte disturbances.
  • Concurrent antacids or supplements: separate administration by at least 2 hours to ensure absorption.
  • Pregnancy and breastfeeding: use only when benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levofloxacine Eg can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Warfarin: potentiates anticoagulant effect, requiring INR monitoring.
  • Cyclosporine: increases levofloxacin plasma concentrations.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heighten risk of central nervous system stimulation.
  • Theophylline: may increase theophylline toxicity.

Moderate Interactions (Monitor Closely)

  • Diabetes medications: possible alteration of glucose control.
  • Corticosteroids: increased risk of tendon rupture.
  • Rifampin: may lower levofloxacin levels, reducing efficacy.
  • Sulfonylureas: potential for enhanced hypoglycaemia.
  • Ergot derivatives: risk of vasospasm and ischemia.

Frequently Asked Questions

Levofloxacine Eg is indicated for a range of bacterial infections, including uncomplicated urinary tract infections, acute respiratory tract infections such as bronchitis and sinusitis, skin and soft‑tissue infections, prostatitis, and uncomplicated gonorrhea. It is prescribed for adults when the causative bacteria are susceptible to levofloxacin.

Levofloxacin blocks two essential bacterial enzymes, DNA gyrase and topoisomerase IV, which are required for DNA replication and transcription. By binding to these enzymes, the drug prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against many Gram‑positive and Gram‑negative organisms.

The specific dose and duration of Levofloxacine Eg are determined by the prescribing clinician based on the type and severity of the infection, patient age, renal function and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Levofloxacine Eg falls under an unknown pregnancy category, and safety data are limited. It should be used only if the potential benefits justify the possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levofloxacin is a third‑generation fluoroquinolone with a broader spectrum against Gram‑positive organisms and better lung penetration compared with ciprofloxacin. Both share similar safety profiles, but levofloxacin often requires once‑daily dosing, whereas ciprofloxacin may need twice‑daily administration, which can affect patient adherence.

Levofloxacine Eg should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Levofloxacine Eg is taken orally, usually with a full glass of water. It can be taken with or without food, but if antacids or supplements containing aluminum, magnesium, calcium or iron are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious adverse events include tendon rupture (especially Achilles), QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, peripheral neuropathy, and hepatic injury. Patients should seek immediate medical attention if they experience sudden joint pain, palpitations, rash, severe diarrhea or signs of liver dysfunction.

Levofloxacine Eg is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones. It should be avoided in patients with a history of tendon disorders related to fluoroquinolone use, those with prolonged QT interval without proper monitoring, and in pregnant or breastfeeding women unless the benefit outweighs the risk. Pediatric use is limited to specific indications approved by regulatory authorities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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