Product image of Levofloxacine Hikma (Levofloxacin) supplied by GNH India

Levofloxacine Hikma

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacine Hikma (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacine Hikma, is a fluoroquinolone presented as an unknown strength/unknown form for intravenous use. It treats a range of serious bacterial infections in adult patients.
GNH India supplies Levofloxacine Hikma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

Levofloxacine Hikma is a fluoroquinolone antibiotic indicated for several serious bacterial infections.

  • Community‑acquired pneumonia: eradicates the causative pathogens and improves respiratory function.
  • Complicated urinary tract infections: eliminates resistant Gram‑negative organisms and resolves infection.
  • Skin and soft tissue infections: reduces bacterial load and promotes healing of infected lesions.
  • Intra‑abdominal infections: provides broad‑spectrum coverage against mixed aerobic and anaerobic flora.
  • Bacterial prostatitis: penetrates prostatic tissue to treat chronic bacterial inflammation.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents DNA unwinding and transcription, leading to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a wide range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacine Hikma may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema or pruritus.
  • Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: cardiac arrhythmia risk in susceptible patients.
  • Severe hypersensitivity: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Precautions & Warnings

Levofloxacine Hikma requires careful consideration of patient‑specific factors before use.

  • Renal impairment: adjust therapy based on creatinine clearance.
  • History of tendon disorders: avoid in patients with prior tendon injury.
  • Cardiac risk: monitor ECG in patients with known QT prolongation.
  • Concomitant CNS stimulants: use caution as seizures may be precipitated.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacine Hikma can affect or be affected by other medicines.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Cyclosporine: increased cyclosporine serum concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may increase risk of CNS stimulation and seizures.
  • Theophylline: potential for elevated plasma theophylline levels.
  • Corticosteroids: heightened risk of tendon rupture when combined.

Frequently Asked Questions

Levofloxacine Hikma is indicated for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft tissue infections, intra‑abdominal infections, and bacterial prostatitis. It is prescribed when a broad‑spectrum fluoroquinolone is appropriate for the identified or suspected pathogen.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing these enzymes from functioning, the drug halts bacterial cell division and leads to rapid bacterial death, providing bactericidal activity against a wide range of Gram‑negative and Gram‑positive organisms.

The specific dose of Levofloxacine Hikma is determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and other clinical factors. Healthcare professionals set the appropriate regimen and duration according to approved guidelines and individual patient needs.

Safety data for levofloxacin in pregnancy and lactation are limited. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Levofloxacine Hikma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Levofloxacin offers broad‑spectrum coverage and convenient once‑daily dosing for many serious infections, often allowing intravenous-to‑oral switch. Compared with beta‑lactams, it may be more effective against resistant Gram‑negative organisms but carries specific risks such as tendon injury and QT prolongation. Choice depends on pathogen susceptibility, patient risk factors, and local resistance patterns.

Levofloxacine Hikma should be stored at ambient temperature, below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight, and extreme temperatures to maintain stability and potency.

Levofloxacine Hikma is supplied for intravenous infusion. The medication is diluted in an appropriate compatible solution and administered over a prescribed period, typically 30–60 minutes, under the supervision of qualified healthcare personnel.

Serious risks include tendon rupture (especially Achilles tendon), QT interval prolongation leading to arrhythmias, severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome, and Clostridioides difficile‑associated diarrhea. Patients should be monitored closely for any signs of these events.

Levofloxacine Hikma is contraindicated in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, uncontrolled epilepsy, or those taking medications that significantly prolong the QT interval without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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